{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:28:19Z","timestamp":1761863299147},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T00:00:00Z","timestamp":1389398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection is the leading cause of liver transplantation in the adult population in the United States. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection occurs in 0.2\u20130.4% of the pediatric population and progression to <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> is uncommon. Liver transplantation for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> in children is rare. In this report, we present a case of pediatric patient with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and multifocal <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> at the age of 13 who underwent successful liver transplantation. While good graft function was initially observed, at one\u00a0month after transplant, he experienced significant hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> recurrence. He was treated with low\u2010accelerating dose regimen antiviral therapy of <jats:styled-content style=\"fixed-case\">PEG\u2010IFN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content>, followed by addition of a protease inhibitor, boceprevir, which led to viral clearance. To our knowledge, this is the first case report describing the post\u2010transplant course of a child transplanted for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>, and the first pediatric case report on using the triple therapy for management of post\u2010liver transplant recurrence of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. This case report demonstrates the need for increased vigilance of surveillance for <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> during childhood.<\/jats:p>","DOI":"10.1111\/petr.12223","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T18:53:49Z","timestamp":1389466429000},"source":"Crossref","is-referenced-by-count":16,"title":["Liver transplantation in a child with multifocal hepatocellular carcinoma hepatitis C and management of post\u2010transplant viral recurrence using boceprevir"],"prefix":"10.1111","volume":"18","author":[{"given":"Saloni","family":"Malik","sequence":"first","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Dekio","sequence":"additional","affiliation":[{"name":"Department of Pathology The Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica W.","family":"Wen","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition The Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20793"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02633.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00519.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260706"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318170af04"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.17914"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/lv.2000.4875"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20042"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.3.10470886"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.3.1800673"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199906000-00005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22709"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200107000-00011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.091"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181bd783c"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21624"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21646"},{"key":"e_1_2_6_20_1","first-page":"637","article-title":"Management of recurrent hepatitis C following liver transplantation","volume":"6","author":"Gonzalez SA","year":"2010","journal-title":"Gastroenterology & Hepatology"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22439"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:24:46Z","timestamp":1696004686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,11]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/petr.12223"],"URL":"https:\/\/doi.org\/10.1111\/petr.12223","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,11]]}}}