{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:35:40Z","timestamp":1790368540678,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>PH type 2 is caused by decreased activity of<jats:styled-content style=\"fixed-case\">GRHPR<\/jats:styled-content>enzyme that eventually leads to<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>and systemic oxalosis. Here, we describe an Iranian pediatric patient with<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>2 and early<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>development who received recommended treatment by undergoing isolated kidney transplantation. Diagnosis criteria included a history of reoccurring calcium oxalate renal stones and elevated oxalate levels combined with liver biopsy and decreased enzymatic activity at age five.<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>prompted transplantation and was performed at age nine. On Day 12 post\u2010op, his serum creatinine level increased. A graft biopsy showed calcium oxalate crystal deposits in renal tubes with no evidence of acute rejection, which resolved with intensive hydration and administration of a potassium citrate solution. Subsequent biopsies confirmed results found in first biopsy. Despite the immunosuppressive therapy, his serum creatinine level increased again after 11\u00a0months. Renal tubular obstruction then led to graft nephrectomy. Pathological analysis of tissue confirmed findings of past biopsies. This was a very rare case of early<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>in<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>2 resulting in a failed isolated kidney transplant. As the<jats:styled-content style=\"fixed-case\">GRHPR<\/jats:styled-content>enzyme is predominantly expressed in liver, we suggest a combined liver\u2010kidney transplant may be beneficial in patients with<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>2.<\/jats:p>","DOI":"10.1111\/petr.12240","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T12:02:17Z","timestamp":1394020937000},"source":"Crossref","is-referenced-by-count":21,"title":["Failure of isolated kidney transplantation in a pediatric patient with primary hyperoxaluria type 2"],"prefix":"10.1111","volume":"18","author":[{"given":"GholamHossein","family":"Naderi","sequence":"first","affiliation":[{"name":"Department of Kidney Transplantation Dr. Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AmirHossein","family":"Latif","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation Dr. Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firouzeh","family":"Tabassomi","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation Dr. Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Taher","family":"Esfahani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1234-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1137-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/864580"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs078"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02760311"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21021"},{"key":"e_1_2_7_8_1","first-page":"41","article-title":"Primary hyperoxaluria","volume":"15","author":"Johnson SA","year":"2004","journal-title":"Saudi J Kidney Dis 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