{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:51:58Z","timestamp":1785401518215,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> is a rare acquired abnormality of the <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> outflow tract in children and adults. <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> can be seen with or without associated congenital heart disease, but the mechanism of its emergence has been poorly understood. Here, we report two cases of <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> that developed after solid organ transplant in childhood. One patient underwent liver and kidney transplant at three\u00a0yr of age for hereditary polycystic disease, and the other had liver transplant at three\u00a0months of age due to uncontrollable high\u2010output failure secondary to a large hepatic hemangioma. Both patients developed mild dynamic <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> outflow tract obstruction and systemic hypertension soon after transplant, both of which resolved by the time of discharge. Transient <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> hypertrophy was observed in both cases. Corticosteroids, cyclosporine <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, and tacrolimus were used as initial immunosuppressants. Both patients developed <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> long after the regression of the initial dynamic <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> outflow tract obstruction. Herein, we report <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> as an atypical late cardiovascular complication after solid organ transplant and postulate that transient post\u2010transplant hyperdynamic <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> outflow tract obstruction and chronic immunosuppressive treatment may lead to subendocardial remodeling resulting in a fibromuscular membranous ridge in susceptible subjects.<\/jats:p>","DOI":"10.1111\/petr.12270","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T07:24:43Z","timestamp":1399879483000},"source":"Crossref","is-referenced-by-count":3,"title":["Acquired discrete subaortic stenosis in solid organ transplant recipients"],"prefix":"10.1111","volume":"18","author":[{"given":"Takeshi","family":"Tsuda","sequence":"first","affiliation":[{"name":"Nemours Cardiac Center Nemours\/Alfred I. duPont Hospital for Children Wilmington DE 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