{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:34:33Z","timestamp":1792074873656,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> is increasingly being recognized as an important cause of renal allograft injury, contributing to significant morbidity and graft loss. There are few controlled trials and no well\u2010established treatment guidelines for <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> in renal transplant recipients. We retrospectively reviewed the outcome of four pediatric renal transplant recipients on a steroid minimization immunosuppression protocol treated with bortezomib for elevated <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> and acute <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> from 2012 to 2013. All patients received four doses of bortezomib 1.3\u00a0mg\/m<jats:sup>2<\/jats:sup> given on days one, four, eight, and 11. All patients also received other treatments prior to bortezomib, which may have included rituximab, methylprednisolone, plasmapheresis, and\/or <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g. While bortezomib in addition to other therapies significantly decreased <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> titers, <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> remained very elevated months after treatment. All four patients had immediate improvement or stabilization of renal function but one eventually lost her graft. There were no adverse events related to bortezomib six\u00a0months after treatment.<\/jats:p>","DOI":"10.1111\/petr.12274","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T07:56:39Z","timestamp":1399881399000},"page":"463-468","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of bortezomib for reducing donor\u2010specific antibodies in children and adolescents on a steroid minimization regimen"],"prefix":"10.1111","volume":"18","author":[{"given":"Stephanie","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Nephrology University of California, Davis Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Gallay","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Transplant Nephrology University of California, Davis Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavjay","family":"Butani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Nephrology University of California, Davis Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31825d1587"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00373.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2009.01254.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02987.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.58.2.259"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36251-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01618.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318190af83"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181c6ff8d"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181fdd9b0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318218e901"},{"key":"e_1_2_7_13_1","first-page":"229","article-title":"Changes in IgG subclasses of donor specific anti\u2010HLA antibodies following bortezomib\u2010based therapy for antibody mediated rejection","author":"Kannabhiran D","year":"2012","journal-title":"Clin Transpl"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a4b91b"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02968.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2012.01.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31823f7eea"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12113"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12129"},{"key":"e_1_2_7_20_1","volume-title":"Treatment of Late Onset De Novo Donor Specific Antibody (DSA)\u2010Mediated Pediatric Kidney Transplant Rejection with Bortezomib","author":"Ghata J","year":"2013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318257acf6"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:11:30Z","timestamp":1695510690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,12]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/petr.12274"],"URL":"https:\/\/doi.org\/10.1111\/petr.12274","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,12]]}}}