{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T03:07:55Z","timestamp":1771211275584,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin C deficiency in developed countries is typically observed in patients with unique clinical conditions such as cystic fibrosis or anorexia nervosa, or in patients on long\u2010term tube feeds. We report here a clinical observation in six pediatric and adolescent patients (median age 17.5\u00a0yr, range 9.8\u201323.5\u00a0yr) with chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> with mucous membrane involvement found to be vitamin C deficient. These patients' baseline serum vitamin C levels ranged from &lt;0.12 to 0.94\u00a0mg\/dL (normal value 0.20\u20131.90\u00a0mg\/dL), with a mean level 0.56\u00a0\u00b1\u00a00.36\u00a0mg\/dL and a median level 0.6\u00a0mg\/dL. Among these patients, signs and symptoms of mucositis failed to respond to standard chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> therapy. After receiving treatment with 2000\u00a0mg of ascorbic acid by mouth, daily patients displayed increased serum vitamin C levels. Clinically, this correlated with a remarkable improvement in patients' mucositis and ability to eat.<\/jats:p>","DOI":"10.1111\/petr.12285","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T07:29:06Z","timestamp":1399879746000},"page":"524-526","source":"Crossref","is-referenced-by-count":17,"title":["Scurvy: A new problem for patients with chronic <scp>GVHD<\/scp> involving mucous membranes; an easy problem to resolve"],"prefix":"10.1111","volume":"18","author":[{"given":"Morris","family":"Kletzel","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Ann and Robert H. Lurie Children's Hospital of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Powers","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Hayes","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.42"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000236392.87203.cc"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5205"},{"key":"e_1_2_7_5_1","first-page":"598","article-title":"SCURVY still with us","volume":"26","author":"Alexander JE","year":"1979","journal-title":"Clin Pediatr"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.09.004"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12285","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:11:23Z","timestamp":1695510683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,12]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/petr.12285"],"URL":"https:\/\/doi.org\/10.1111\/petr.12285","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,12]]}}}