{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:43:18Z","timestamp":1762004598145},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,14]],"date-time":"2014-06-14T00:00:00Z","timestamp":1402704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content> is an <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010linked primary immunodeficiency characterized by microthrombocytopenia, eczema, recurrent infections, and increased incidence of autoimmunity and malignancy. <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> is the only curative treatment for <jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content>. Herein, we report the case of a 17\u2010yr\u2010old boy with <jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content> who received an unrelated <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> while in complete remission of diffuse large <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphoma after chemotherapy. Pretransplant conditioning consisted of fludarabine, busulfan, and total body irradiation (4\u00a0Gy). GvHD prophylaxis consisted of tacrolimus and short\u2010course methotrexate. Following <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, rapid and stable engraftment was observed. Platelet count gradually increased, and the generalized eczema improved. The patient developed grade II acute GvHD and limited chronic GvHD on days 30 and 210, respectively, which resolved with immunosuppressive treatment. Symptoms caused by the reactivation of human herpes virus\u20106, <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> virus, and <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> were observed from days 21, 60, and 96, respectively; they were resolved after conservative treatment and acyclovir administration. No other regimen\u2010related toxicity was observed. Complete donor bone marrow chimerism was achieved one\u00a0month after transplantation. RIST is an effective therapeutic option for older children with <jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content> accompanied by malignant lymphoma.<\/jats:p>","DOI":"10.1111\/petr.12297","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T18:48:37Z","timestamp":1402944517000},"source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of non\u2010Hodgkin's lymphoma using R\u2010CHOP in a patient with Wiskott\u2013Aldrich syndrome followed by a reduced\u2010intensity stem cell transplant"],"prefix":"10.1111","volume":"18","author":[{"given":"Yuhki","family":"Koga","sequence":"first","affiliation":[{"name":"Department of Pediatrics Graduate school of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate school of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Suminoe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate school of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouichi","family":"Ohga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate school of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate school of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00917.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.23.6932"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23393"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1598"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282f30448"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2010.02.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-076679"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198004173021604"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12049"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06297.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-448118"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4081\/pr.2011.s2.e11"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12114"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03269.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.10.007"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.31"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-319376"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12297","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:08:28Z","timestamp":1695510508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,14]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/petr.12297"],"URL":"https:\/\/doi.org\/10.1111\/petr.12297","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,14]]}}}