{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:40:53Z","timestamp":1695512453084},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombocytopenia is a major risk factor for cirrhotic liver disease. Patients with thrombocytopenia may have esophageal or gastric varices secondary to portal hypertension, leading to variceal bleeding which exposes the liver to further damage. Here, we present a female pediatric patient with <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>, whose progressive thrombocytopenia was successfully controlled by romiplostim, a <jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> receptor agonist. The patient developed bloody diarrhea at four\u00a0yr of age, and was subsequently diagnosed with <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> when seven\u00a0yr old. While <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> was well\u2010controlled by immunomodulators, the patient's thrombocytopenia gradually progressed resulting in petechiae (platelet count of 11\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L) when she was 10\u00a0yr and four\u00a0months old. She responded poorly to immunoglobulin and corticosteroids. Weekly subcutaneous injection of romiplostim was therefore initiated, and platelet counts were maintained over at 50\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L. She was able to undergo successful <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> without platelet transfusion seven\u00a0months after the initiation of romiplostim. Romiplostim was not required after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> with improved platelet counts. This case report suggests that romiplostim may be effective in the treatment of thrombocytopenic children with liver cirrhosis and portal hypertension, and in eliminating the need for platelet transfusion during the peri\u2010transplant period.<\/jats:p>","DOI":"10.1111\/petr.12308","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T06:27:41Z","timestamp":1405060061000},"source":"Crossref","is-referenced-by-count":4,"title":["Romiplostim treatment allows for platelet transfusion\u2010free liver transplantation in pediatric thrombocytopenic patient with primary sclerosing cholangitis"],"prefix":"10.1111","volume":"18","author":[{"given":"Kei","family":"Minowa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Arai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mureo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Transplant Center National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seisuke","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Transplant Center National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pathology National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Hepatology National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naho","family":"Obayashi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Division of Hematology National Center for Child Health and Development (NCCHD) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809103391107"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60203-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-150078"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-313908"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1172-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2011.619601"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2011.629401"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01641.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.25879"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.10.2720.bloodjournal85102720"},{"key":"e_1_2_7_12_1","first-page":"1645","article-title":"Serum 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