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Development of cutaneous <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> has been described in adult <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>x recipients, although it is extremely rare in children. We describe two Caucasian children who developed cutaneous <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> beyond three\u00a0yr post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>x. Both developed severe photosensitivity, actinic keratosis and required curative surgical excision of the cutaneous <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> lesions. Neither patient developed metastatic lesions nor had allograft dysfunction as a result of the <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> or the change in medical treatments. The effect of voriconazole on the development of malignant skin lesions is discussed and a recommendation on dermatologic surveillance, preventive measures against phototoxicity and early treatment of <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> are provided.<\/jats:p>","DOI":"10.1111\/petr.12320","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T05:32:56Z","timestamp":1404970376000},"source":"Crossref","is-referenced-by-count":22,"title":["Cutaneous squamous cell carcinoma in two pediatric lung transplant patients on prolonged voriconazole treatment"],"prefix":"10.1111","volume":"18","author":[{"given":"Jackson Y.","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kuzel","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Mullen","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Lien","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Conrad","sequence":"additional","affiliation":[{"name":"Pediatric Lung and Heart\u2010Lung Transplant Program Stanford University Stanford CA USA"},{"name":"Department of Pediatrics Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loretta","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000437434.42851.d4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12115"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.08.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110087"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00492.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02635.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.03.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01076.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03375.x"},{"key":"e_1_2_7_11_1","first-page":"242","article-title":"Voriconazole \u2013 better chances for patients with invasive mycoses","volume":"7","author":"Ghannoum MA","year":"2002","journal-title":"Eur J Med Res"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.6.755"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.05.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/524669"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01596.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02418.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/511685"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.033"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.05.022"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2011.09.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11196.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.705"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182566311"},{"key":"e_1_2_7_24_1","unstructured":"Division of Special Pathogen and Immunologic Drug Products Center for Drug Evalaution and Research Food and Drug Administration.Background document for the antiviral drug products advisory committee meeting. 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