{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:54:37Z","timestamp":1773388477765,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of donors with coagulation <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> deficiency is controversial, and there are no current protocols for peri\u2010transplant management. We herein describe the first reported case of a pediatric <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> from an asymptomatic donor with mild coagulation <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> deficiency. A 32\u2010yr\u2010old female was evaluated as a donor for her 12\u2010month\u2010old daughter with biliary atresia. The donor's pretransplant coagulation tests revealed asymptomatic mild coagulation <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> deficiency (<jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> activity 60.8%). Freeze\u2010dried human blood coagulation <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> concentrate was administered before the dissection of the liver and 12\u00a0h afterwards by bolus infusion (40\u00a0U\/kg) and was continued on <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 1. The bleeding volume at <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> was 590\u00a0mL. On <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 1, 3, 5, and 13, the coagulation <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> activity of the donor was 121.3%, 130.6%, 114.6%, and 50.2%, respectively. The donor's post\u2010transplant course was uneventful, and the recipient is currently doing well at 18\u00a0months after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> activity of the donor and recipient at nine\u00a0months after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> was 39.2% and 58.0%, respectively. <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> from donors with mild coagulation <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> deficiency could be performed effectively and safely using peri\u2010transplant short\u2010term coagulation <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> replacement and long\u2010term monitoring of the plasma <jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> level in the donor.<\/jats:p>","DOI":"10.1111\/petr.12358","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T10:32:08Z","timestamp":1422613928000},"source":"Crossref","is-referenced-by-count":1,"title":["Living donor liver transplantation from an asymptomatic donor with mild coagulation factor IX deficiency: Report of a case"],"prefix":"10.1111","volume":"18","author":[{"given":"Yukihiro","family":"Sanada","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke City Tochigi Japan"},{"name":"Department of Surgery Jichi Medical University Shimotsuke City Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Sasanuma","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke City Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunaru","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke City Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazue","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke City Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke City Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke City Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke City Tochigi 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