{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:03:40Z","timestamp":1778605420305,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our center has offered thymoglobulin induction with steroid minimization to our pediatric renal transplant patients for the last 10\u00a0yr. Steroid minimization or avoidance has shown favorable results in survival, kidney function, and growth in previous studies of pediatric patients. We report our experience with this protocol over the past 10\u00a0yr with respect to patient\/graft survival, acute rejection episodes, renal function, linear growth, bone density, cardiovascular risk factors, and opportunistic infections. A retrospective chart review was performed for pediatric renal transplant patients on the steroid\u2010minimized protocol between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2002 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011 on an intention to treat basis. Patient demographics, height, weight, serum creatinine, i<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>, biopsies, and survival data were collected. Height and weight <jats:italic>z<\/jats:italic>\u2010scores were calculated with <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>pi<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nfo 7, using the <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content> 2000 growth charts. Survival was calculated using <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier analysis. e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was calculated using the original and modified <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chwartz equations. Forty\u2010four pediatric patients were identified, aged 13\u00a0months to 19\u00a0yr. Five\u2010yr survival was 95.5% for males and 94.4% for females. Only five patients had biopsy\u2010proven ACR, two of which were at more than 12\u00a0months post\u2010transplantation. Height delta <jats:italic>z<\/jats:italic>\u2010scores from transplant to one, three, and five\u00a0yr were 0.34, 0.38, and 0.79, respectively. Weight delta <jats:italic>z<\/jats:italic>\u2010scores from transplant to one, three, and five\u00a0yr were 0.87, 0.79, and 0.84, respectively. Mean original <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chwartz e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was 84.3\u00a0\u00b1\u00a015.8\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, modified <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chwartz e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was 59.3\u00a0\u00b1\u00a011.5\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, and i<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was 64.2\u00a0\u00b1\u00a08.5\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> at three\u00a0yr. Of 18 subjects who had a bone density exam, none had a <jats:italic>z<\/jats:italic>\u2010score less than \u22122 on DEXA exam at one\u2010yr post\u2010transplantation. Fifty\u2010one percent of patients were on antihypertensives at the time of transplant compared with 43% at one\u2010yr post\u2010transplantation. Three\u00a0yr post\u2010transplantation, the average <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> was &lt;100\u00a0mg\/dL, and average total cholesterol was &lt;200\u00a0mg\/dL. There were no clinical episodes of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection. A steroid\u2010minimized protocol with thymoglobulin induction is safe and provides favorable improvement in linear growth, stable graft function, stable or improved cardiovascular risk factors, and normal bone density in pediatric renal transplant patients.<\/jats:p>","DOI":"10.1111\/petr.12374","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T05:13:56Z","timestamp":1413263636000},"page":"816-821","source":"Crossref","is-referenced-by-count":21,"title":["Single\u2010center experience in pediatric renal transplantation using thymoglobulin induction and steroid minimization"],"prefix":"10.1111","volume":"18","author":[{"given":"Jillian K.","family":"Warejko","sequence":"first","affiliation":[{"name":"St. Louis Children's Hospital Saint Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Paul","family":"Hmiel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Department of Pediatrics Washington University Medical School Saint Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00319.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac6833"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03047.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050410"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000092950.54184.67"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04145.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12186"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.6.502"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0787-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000189447"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.58.2.259"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12034"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12374","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:06:17Z","timestamp":1695549977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,14]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/petr.12374"],"URL":"https:\/\/doi.org\/10.1111\/petr.12374","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,14]]}}}