{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:22:39Z","timestamp":1781295759815,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T00:00:00Z","timestamp":1413504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several transplant strategies for <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>1 have been proposed, and <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> is performed to correct the metabolic defects. The patients with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>1 often suffer from <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> and require simultaneous <jats:styled-content style=\"fixed-case\">LKT<\/jats:styled-content>, which leads to a long wait due to the shortage of suitable organ donors. Five patients with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>1 underwent <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> at our institute. Three of the five patients were under dialysis before <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>, while the other two patients were categorized as <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 3. An isolated <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> was successfully performed in all but our first case, who had complicated postoperative courses and consequently died due to sepsis after retransplantation. The renal function of the patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 3 was preserved after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>. On the other hand, our second case with <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> underwent successful <jats:styled-content style=\"fixed-case\">LDKT<\/jats:styled-content> six\u00a0months after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>, and our infant case is waiting for the subsequent <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> without any post\u2010<jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> complications after the early establishment of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. In conclusion, a two\u2010step transplant strategy may be needed as a life\u2010saving option for patients with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>1 and may be possible even in small infants with systemic oxalosis. While waiting for a subsequent <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>, an early resumption of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> should be considered from the perspective of the long\u2010term requirement of <jats:styled-content style=\"fixed-case\">RRT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12376","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T05:58:32Z","timestamp":1413525512000},"source":"Crossref","is-referenced-by-count":30,"title":["Two\u2010step transplantation for primary hyperoxaluria: A winning strategy to prevent progression of systemic oxalosis in early onset renal insufficiency cases"],"prefix":"10.1111","volume":"19","author":[{"given":"Kengo","family":"Sasaki","sequence":"first","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo 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