{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:18:18Z","timestamp":1781111898228,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> encephalitis in a seven\u2010yr\u2010old child with <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>h+ <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>. Two\u00a0months after an allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> from his <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> mismatched mother, the patient showed an altered sensorium, generalized seizures, and a left hemiparesis. Brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> demonstrated multiple lesions highly suggestive for viral encephalitis. Blood and <jats:styled-content style=\"fixed-case\">CSF PCR<\/jats:styled-content> analyses were negative for the most common viruses involved in immunocompromised patients including <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>. A cerebral biopsy was performed, which showed intense gliosis and perivascular lymphocytic cuffing. <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> analysis performed on brain tissue was positive only for the <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> genome, while extensive investigations for other viral infections were negative. The patient's neurological symptoms rapidly worsened and he died two\u00a0months later. This case report suggests that in patients presenting neurological and radiological signs of encephalitis after an <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, an <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> involvement should be considered, even in the absence of <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> and blood <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> virus detection.<\/jats:p>","DOI":"10.1111\/petr.12386","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T07:29:44Z","timestamp":1415777384000},"source":"Crossref","is-referenced-by-count":9,"title":["Proven <scp>E<\/scp>pstein\u2013<scp>B<\/scp>arr encephalitis with negative <scp>EBV<\/scp>\u2010<scp>DNA<\/scp> load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"19","author":[{"given":"Walter","family":"Barberi","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Perrone","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Paola","family":"Iori","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Fernando","family":"Torelli","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Testi","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Moleti","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ceglie","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Papoff","sequence":"additional","affiliation":[{"name":"Department of 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