{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:58:01Z","timestamp":1725015481460},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> may lead to the development of <jats:styled-content style=\"fixed-case\">ESLD<\/jats:styled-content> in late childhood and, consequently, contributes to the need for liver transplantation. The aim of this study was to examine post\u2010transplant outcomes in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010positive pediatric patients with <jats:styled-content style=\"fixed-case\">ESLD<\/jats:styled-content> from any cause and to determine the impact of the <jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> scoring system, introduced in February 2002, on post\u2010transplant patient and graft survival. A retrospective analysis of the <jats:styled-content style=\"fixed-case\">UNOS<\/jats:styled-content> database from 1994 to 2010 was performed to assess graft and patient survival in pediatric <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010seropositive liver transplant recipients. Graft survival and patient survival comparing subjects in the pre\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era and post\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era were analyzed using Kaplan\u2013Meier statistics. Factors associated with survival were identified using Cox regression analysis. Of 120 pediatric <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> transplant recipients, 80 were transplanted in the pre\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era and 40 were transplanted post\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content>. Median serum total bilirubin, <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>, and creatinine were 4.8\u00a0mg\/dL, 1.6, and 0.7\u00a0mg\/dL in the pre\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era vs. 5.5\u00a0mg\/dL, 1.7, and 0.6\u00a0mg\/mL, respectively, in the post\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era (p <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). One\u2010yr graft survival in the pre\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> vs. post\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era was 65.0% and 89.7%, respectively (p\u00a0&lt;\u00a00.01); corresponding three\u2010yr graft survival was 57.3% vs. 76.2% (p\u00a0=\u00a00.04). One\u2010yr patient survival in the pre\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> vs. post\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era was 79.0% and 97.5%, respectively (p\u00a0&lt;\u00a00.01); corresponding three\u2010yr survival was 79.0% vs. 89.4% (p\u00a0=\u00a00.17). Twenty\u2010eight patients (23.3%) were retransplanted: 24 (30%) in the pre\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era (median time to retransplant 272\u00a0days) and four (10%) in the post\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era (median time to retransplant 586\u00a0days). Early follow\u2010up demonstrates a trend toward improved pediatric <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> liver transplant graft and patient survival in the post\u2010<jats:styled-content style=\"fixed-case\">PELD<\/jats:styled-content> era. Superior outcomes may be attributed to pretransplant factors, improved surgical technique and better treatment options for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection.<\/jats:p>","DOI":"10.1111\/petr.12408","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T11:51:40Z","timestamp":1418298700000},"page":"153-163","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes in pediatric hepatitis <scp>C<\/scp> transplant recipients: Analysis of the <scp>UNOS<\/scp> database"],"prefix":"10.1111","volume":"19","author":[{"given":"Meera","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjeeta","family":"Bahirwani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\/Hepatology University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H.","family":"Levine","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saloni","family":"Malik","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\/Hepatology University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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