{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:51:33Z","timestamp":1773895893486,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present a case of a three\u2010yr\u2010old child with a history of multisystem Langerhans cell histiocytosis treated with systemic chemotherapy, who developed progressive liver failure and received an orthotopic split liver transplant while continuing on chemotherapy. One\u00a0month following transplant, he developed acute graft\u2010vs.\u2010host disease of the skin and gastrointestinal tract. Peripheral blood chimerism studies post\u2010transplant demonstrated an increasing predominance of donor lymphocytes and granulocytes. Shortly after, the patient developed vitiligo, and two\u00a0yr after transplantation, the patient developed skin manifestations of psoriasis. We discuss and review the current literature, which demonstrates that chimerism following liver transplantation is rare and in our patient may be related to his profound immunosuppression around the time of liver transplant as well the development of acute graft\u2010versus\u2010host disease. While autoimmune disease can occur after solid organ and stem cell transplant, our patient developed skin manifestations of autoimmunity after liver transplantation, which is also rarely described.<\/jats:p>","DOI":"10.1111\/petr.12412","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T06:21:46Z","timestamp":1418797306000},"source":"Crossref","is-referenced-by-count":11,"title":["Bone marrow engraftment and associated dermatologic sequelae in a three\u2010yr\u2010old after liver transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"Johanna","family":"Sheu","sequence":"first","affiliation":[{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo P.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Department of Dermatology Harvard Medical School Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Degar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Harvard Medical School Boston Children's Hospital Dana Farber Cancer Institute Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine N.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Medicine Harvard Medical School Boston Children's Hospital Dana Farber Cancer Institute Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Fawaz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Harvard Medical School Boston Children's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer K.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Harvard Medical School Boston Children's Hospital Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pathology Harvard Medical School Boston Children's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heung B.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Harvard Medical School Boston Children's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer T.","family":"Huang","sequence":"additional","affiliation":[{"name":"Instructor in Dermatology Harvard Medical School Dermatology Program Boston Children's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2628"},{"key":"e_1_2_5_3_1","first-page":"5240","article-title":"Graft\u2010versus\u2010host disease after liver transplantation: A comprehensive literature review","volume":"18","author":"Akbulut S","year":"2012","journal-title":"World J 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