{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:26:25Z","timestamp":1778070385086,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PTMS<\/jats:styled-content> describes the presence of \u22653 cardiometabolic risk factors that include obesity, hypertension, dyslipidemia, and <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>. The prevalence of the clustering of \u22653 cardiometabolic risk factors or central obesity has not been studied in pediatric LT recipients. Single\u2010center, cross\u2010sectional study. Inclusion criteria: <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients 2\u201318 yr\u2010old, at least one\u00a0yr post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. Exclusion criteria: recipients of liver retransplants or multivisceral transplants. Eighty\u2010seven patients were identified. Median age was 9.8\u00a0yr (range 2\u201318), median time since <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> was 6.9 yr (range 1\u201317). The most common indication for <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> was biliary atresia (56%), and the most frequently used immunosuppressant was tacrolimus (80%). The prevalence of overweight and obesity was 21% and 5%, respectively. Central obesity affected 14%, hypertension 44%, <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> 27%, low <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> 20%, and hypertriglyceridemia 39% of patients. The prevalence of \u22653 cardiometabolic risk factors was 19%. Fifty percent of the overweight\/obese patients had \u22653 risk factors. Time since transplant, immunosuppression and renal function were not different between those with &lt;3 or \u22653 risk factors. Clustering of cardiometabolic risk factors is prevalent in pediatric LT recipients, suggesting an increased risk of future CV events.<\/jats:p>","DOI":"10.1111\/petr.12425","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T06:17:05Z","timestamp":1420697825000},"page":"175-181","source":"Crossref","is-referenced-by-count":23,"title":["Overweight, central obesity, and cardiometabolic risk factors in pediatric liver transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"Marc","family":"Dagher","sequence":"first","affiliation":[{"name":"University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky L.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics SickKids Transplant Centre Hospital for Sick Children University of Toronto Toronto ON 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