{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:26:09Z","timestamp":1793039169347,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>u, combined with <jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>\u2010guided dosing, is associated with fewer graft failures\/relapses and lower toxicity in pediatric <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. We aimed this retrospective study for comparison of weight\u2010 and age\u2010based dosing in terms of clinical outcomes such as time to engraftment, early complications, <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OS<\/jats:styled-content>, and toxicity profiles in children receiving iv <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>u. Sixty\u2010one children who underwent HSCT from April 2010 to February 2013 by means of a Bu\u2010based conditioning regimen and completed 100 days after transplantation at Ankara Children?s Hematology and Oncology Hospital Bone Marrow Transplantation Unit were enrolled in this study. <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> and neutropenic fever occurred more frequently in the weight\u2010based dosing group. We found a statistically significant correlation between <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>u dose and the incidence of <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.26, p\u00a0=\u00a00.04). Multivariate analysis showed only weight\u2010based dosing of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>u was a significant predictor of <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a09.46; p\u00a0=\u00a00.009). However, no relationship was found between two groups in terms of hemorrhagic cystitis, engraftment syndrome, acute or chronic <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>, time to engraftment, chimerism, <jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OS<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content> rates. Weight\u2010based dosing of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>u may cause higher incidence of <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> and early infectious complications at the places where <jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>u cannot be performed.<\/jats:p>","DOI":"10.1111\/petr.12430","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T06:26:01Z","timestamp":1423463161000},"page":"307-315","source":"Crossref","is-referenced-by-count":11,"title":["Clinical comparison of weight\u2010 and age\u2010based strategy of dose administration in children receiving intravenous busulfan for hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"D.","family":"G\u00fcrlek G\u00f6k\u00e7ebay","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Azik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Isik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Tavil","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Tunc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara 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