{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:17:13Z","timestamp":1788466633905,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>OM<\/jats:styled-content> is a painful inflammatory condition of the oral mucosa, derived from the toxic effects of chemotherapy and radiotherapy. High OM<\/jats:styled-content> severity is frequently present in HSCT<\/jats:styled-content> pediatric patients, who exhibit multiple painful ulcers that limit their mastication and swallowing, leading to poor nutritional status. Few studies have demonstrated OM<\/jats:styled-content> clinical outcomes in young patients undergoing HSCT<\/jats:styled-content>. Feasibility of oral care and LLLT<\/jats:styled-content> on OM<\/jats:styled-content> prophylaxis and treatment is also poorly discussed. The aim of this study was to describe a specialized oral care protocol that included LLLT<\/jats:styled-content> for pediatric patients undergoing transplantation and to demonstrate the clinical outcomes after OM<\/jats:styled-content> prevention and treatment. Data from OM<\/jats:styled-content>\u2010related morbidity were collected from 51 HSCT<\/jats:styled-content> pediatric patients treated daily with LLLT<\/jats:styled-content>, followed by standard oral care protocols. All the patients, even infants and young children, accepted the daily oral care and LLLT<\/jats:styled-content> well. The majority (80.0%) only exhibited erythema in the oral mucosa, and the maximum OM<\/jats:styled-content> degree was WHO II<\/jats:styled-content>. Patients who had undergone autologous and HLA<\/jats:styled-content>\u2010haploidentical transplants showed OM<\/jats:styled-content> with the lowest severity. The frequency of total body irradiation and methotrexate prescriptions was higher in adolescents when compared with infants (p\u00a0=\u00a00.044), and adolescents also exhibited OM<\/jats:styled-content> more severely than infants and young children. We found that good clinical outcomes were obtained using this therapy, mainly in regard to the control of OM<\/jats:styled-content> severity and pain reduction in the oral cavity. Specialized oral care, including LLLT<\/jats:styled-content>, is feasible and affordable for HSCT<\/jats:styled-content> pediatric patients, although some adaptation in the patient's oral hygiene routine must be adopted with help from parents\/companions and clinical staff.<\/jats:p>","DOI":"10.1111\/petr.12440","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T12:27:34Z","timestamp":1423830454000},"page":"316-325","source":"Crossref","is-referenced-by-count":44,"title":["Oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation: Clinical outcomes in a context of specialized oral care using low\u2010level laser therapy"],"prefix":"10.1111","volume":"19","author":[{"given":"Fernanda de Paula","family":"Eduardo","sequence":"first","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Mello","family":"Bezinelli","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Lima Corr\u00eaa","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Marques da Gra\u00e7a","family":"Lopes","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Folloni","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Brumatti","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Sgaroni Camargo","family":"Vince","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Milani Prandini","family":"de Azambuja","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Vogel","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Hamerschlak","sequence":"additional","affiliation":[{"name":"Unit of Bone Marrow Transplantation Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Correa","sequence":"additional","affiliation":[{"name":"General Pathology Department School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2201"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2050"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-6-13"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12094"},{"key":"e_1_2_8_6_1","first-page":"CD001973","article-title":"Interventions for treating oral mucositis for patients with cancer receiving treatment","volume":"8","author":"Clarkson JE","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1605-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28592"},{"key":"e_1_2_8_9_1","first-page":"16","article-title":"Molecular mechanisms of cell proliferation induced by low power laser irradiation","volume":"12","author":"Gao X","year":"2009","journal-title":"J Biomed Sci"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10107"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20589"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20481"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.2.028002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2928"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20943"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1223-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0055I"},{"key":"e_1_2_8_18_1","volume-title":"Handbook for Reporting Results of Cancer Treatment","author":"WHO (World Health Organization)","year":"1979"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2225"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.353"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.184"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20277"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703771"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e32835f3e8c"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.08.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/104454702320901107"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2144"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03262791"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2009.2699"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318192cb8e"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2012.3327"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12090"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705480"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.02.006"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12440","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:14:49Z","timestamp":1696205689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,13]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/petr.12440"],"URL":"https:\/\/doi.org\/10.1111\/petr.12440","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,13]]}}}