{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:19:18Z","timestamp":1782184758486,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a 16\u2010yr\u2010old female who developed AN within a month after renal transplantation and its resolution after switching from tacrolimus to cyclosporine. Her initial maintenance immunosuppressive regimen after renal transplantation consisted of tacrolimus, mycophenolate, and steroid. She had 7\u00a0kg weight loss within the first month of transplant with subsequent 10, 12, 17, and 19\u00a0kg loss after three, five, seven, and nine months of transplant, respectively. Besides weight loss and disturbances in body image, the patient developed alopecia, bradycardia, and persistent secondary amenorrhea. Upon switching to cyclosporine from tacrolimus nine months after transplant, she started regaining weight with 5\u00a0kg gain within two months and 10\u00a0kg after four months. She restarted her menstrual cycle, alopecia and bradycardia resolved, and her body image disturbance improved. Here, we describe a very unusual neuropsychiatric side effect of tacrolimus and its resolution with another calcineurin inhibitor, cyclosporine, in an adolescent renal transplant recipient.<\/jats:p>","DOI":"10.1111\/petr.12442","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T06:25:55Z","timestamp":1423463155000},"source":"Crossref","is-referenced-by-count":6,"title":["Anorexia nervosa in a pediatric renal transplant recipient and its reversal with cyclosporine"],"prefix":"10.1111","volume":"19","author":[{"given":"Gyongyi","family":"Okechuku","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Pediatrics Shands Children's Hospital University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Boulos","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Pediatrics Shands Children's Hospital University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lettie","family":"Herman","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Pediatrics Shands Children's Hospital University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Pediatrics Shands Children's Hospital University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10222"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199912)26:4<397::AID-EAT5>3.0.CO;2-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38569.471007.AE"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01781.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04800908"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2003.00028.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410273311702"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2011.595396"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1994.tb01305.x"},{"key":"e_1_2_6_13_1","first-page":"3175","article-title":"Neurologic complications of FK 506","volume":"23","author":"Eidelman BH","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2000.tb01004.x"},{"issue":"5","key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1399-0012.1997.tb00843.x","article-title":"Evaluation of neurotoxicity in pediatric renal transplant recipients treated with tacrolimus (FK 506)","volume":"1","author":"Neu AM","year":"1997","journal-title":"Clin Transplant"},{"key":"e_1_2_6_16_1","first-page":"21","article-title":"Hyperlipidemia and obesity after renal transplantation","volume":"6","author":"Teplan V","year":"2001","journal-title":"Ann Transplant"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1572-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199310000-00008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12020"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00840.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199704150-00013"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.t01-1-00042.x"},{"key":"e_1_2_6_23_1","unstructured":"TholkingG SiatsL FortmannC et\u00a0al.Tacrolimus metabolism rate influences the kidney function after liver transplantation Abstract 2013 ATC (American Transplant Congress). Abstract number: D1698."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1429.014"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.03.019"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP71482"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T15:55:31Z","timestamp":1747583731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/petr.12442"],"URL":"https:\/\/doi.org\/10.1111\/petr.12442","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,9]]}}}