{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:15Z","timestamp":1789609215894,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have demonstrated the safety of <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible pediatric <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> using preoperative plasmapheresis and rituximab; however, no reports have described the timing and dosage of rituximab administration for pediatric <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>. This study aimed to describe a safe and effective dosage and timing of rituximab for patients undergoing pediatric <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> based on the experience of our single center. A total of 192 <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>s in 187 patients were examined. These cases included 29 <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>s in 28 patients. Rituximab was used beginning in January 2004 in recipients older than two\u00a0yr of age (first period: 375\u00a0mg\/m<jats:sup>2<\/jats:sup> in two cases; second period: 50\u00a0mg\/m<jats:sup>2<\/jats:sup> in two cases; and 200\u00a0mg\/m<jats:sup>2<\/jats:sup> in eight cases). Two patients who received 375\u00a0mg\/m<jats:sup>2<\/jats:sup> rituximab died of <jats:italic>Pneumocystis carinii<\/jats:italic> pneumonia and hemophagocytic syndrome. One patient who received 50\u00a0mg\/m<jats:sup>2<\/jats:sup> rituximab required retransplantation as a consequence of antibody\u2010mediated complications. All eight patients administered 200\u00a0mg\/m<jats:sup>2<\/jats:sup> survived, and the mean <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20<jats:sup>+<\/jats:sup> lymphocyte count was 0.1% at the time of <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>. In the preoperative management of patients undergoing pediatric <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>, the administration of 200\u00a0mg\/m<jats:sup>2<\/jats:sup> rituximab three\u00a0wk prior to <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> was safe and effective.<\/jats:p>","DOI":"10.1111\/petr.12445","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T06:39:15Z","timestamp":1424241555000},"page":"279-286","source":"Crossref","is-referenced-by-count":28,"title":["The impact of rituximab in <scp>ABO<\/scp>\u2010incompatible pediatric living donor liver transplantation: The experience of a single center"],"prefix":"10.1111","volume":"19","author":[{"given":"Noriki","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Sanada","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiichi","family":"Wakiya","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizen","family":"Urahashi","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sasanuma","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehito","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunaru","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Jichi Medical University Shimotsuke\u2010shi Tochigi\u2010ken Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-010-4437-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92082-S"},{"key":"e_1_2_7_4_1","first-page":"489","article-title":"Antibody\u2010mediated rejection of human orthotopic liver allografts. 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