{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:26:43Z","timestamp":1765546003902},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been proposed that circulating <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s play a role in graft survival after liver transplantation. The aim was to analyze the relationship between the number of <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s before and after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> and liver function, immune biomarkers, and clinical outcomes in pediatric patients. We studied 15 pairs of adult healthy liver donors and pediatric recipients with <jats:styled-content style=\"fixed-case\">ESLD<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45+ cell number was measured in the blood via flow cytometry, and plasma levels of immune biomarkers \u2013 via <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45+ cell number in the recipients decreased within the first week after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>. The cell number before <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> was negatively correlated with the plasma levels of CRP and the development of graft dysfunction in the early post\u2010transplant period. After <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45+ cell number was positively correlated with the pretransplant plasma level of <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>40L, a T\u2010cell activation marker. In adult liver donors, the cell number did not change within the first week after liver resection and was lower than in pediatric recipients. The results suggest that in pediatric recipients, the <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content> number may be associated with graft function and could be regarded as a potential predictor of the clinical outcome after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12482","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T09:19:35Z","timestamp":1430990375000},"page":"531-537","source":"Crossref","is-referenced-by-count":7,"title":["The hematopoietic stem cell number in the peripheral blood of pediatric recipients correlates with the outcome after living donor liver transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"Sergey V.","family":"Gautier","sequence":"first","affiliation":[{"name":"V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs Moscow Russian Federation"},{"name":"Department of Transplantology and Artificial Organs I.M. Sechenov Fist Moscow State Medical University Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga P.","family":"Shevchenko","sequence":"additional","affiliation":[{"name":"V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs Moscow Russian Federation"},{"name":"Department of Transplantology and Artificial Organs I.M. Sechenov Fist Moscow State Medical University Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga M.","family":"Tsirulnikova","sequence":"additional","affiliation":[{"name":"V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivada M.","family":"Kurabekova","sequence":"additional","affiliation":[{"name":"V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana A.","family":"Lugovskaya","sequence":"additional","affiliation":[{"name":"Russian Medical Academy of Postgraduate Education Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena V.","family":"Naumova","sequence":"additional","affiliation":[{"name":"Russian Medical Academy of Postgraduate Education Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina E.","family":"Tsirulnikova","sequence":"additional","affiliation":[{"name":"V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir V.","family":"Dolgov","sequence":"additional","affiliation":[{"name":"Russian Medical Academy of Postgraduate Education Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"54","article-title":"Liver transplantation in children: Six\u2010year experience analysis","author":"Gautier SV","year":"2014","journal-title":"Vestnik transplantologii i iskusstvennykh organov"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.5.465"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21491"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2453"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12616"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.201"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0333"},{"key":"e_1_2_7_9_1","first-page":"805","article-title":"Mobilization of peripheral blood hematopoietic stem cells following liver resection surgery","volume":"51","author":"Silvestro G","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-008-9091-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04217-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03698.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310135"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5417.1168"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/81326"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.171488"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-008-3836-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.07.004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.06.072"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.020"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488806778226759"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1779"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.17.2100"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21408"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1515\/9783110224641.124","article-title":"Plasma levels of soluble CD30 and CD40L in pediatric patients after liver transplantation","author":"Shevchenko OP","year":"2012","journal-title":"Advances in Clinical Chemistry and Laboratory Medicine"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01182.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01407.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2458-z"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00100-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.04.004"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318269e68d"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12482","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:57:27Z","timestamp":1696168647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/petr.12482"],"URL":"https:\/\/doi.org\/10.1111\/petr.12482","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]}}}