{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:25:58Z","timestamp":1790371558995,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:00:00Z","timestamp":1436313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> incompatibility between donor and recipient is not considered a barrier to successful allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Nevertheless, conflicting data still exist about the influence of <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> incompatibility on transplant outcome in pediatric patients with thalassemia. Fifty\u2010one children with beta\u2010thalassemia major who underwent allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> were enrolled this study. Twenty\u2010three of them (45%) received an <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible transplant [minor <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> mismatch: six (26%), major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> mismatch: fourteen (61%), and bidirectional mismatch: three (13%)]. In this study, <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> incompatibility did not significantly impair <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VOD<\/jats:styled-content>, neutrophil and platelet engraftment, <jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TFS<\/jats:styled-content>. Particularly in major and bidirectional <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010mismatched patients, a delayed erythroid recovery was recorded as compared to the group receiving an <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010compatible graft (median time, 31 and 38\u00a0days vs. 19.5\u00a0days; p: 0.02 and p: 0.03). Median time to red cell transfusion independence was significantly longer in major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible patients (median time, 87\u00a0days vs. 32\u00a0days; p: 0.001). Therefore, whenever feasible, major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010mismatched donors should be avoided in <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients, to prevent delayed erythroid recovery with prolonged <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion needs and impaired quality of life.<\/jats:p>","DOI":"10.1111\/petr.12552","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T07:30:34Z","timestamp":1436340634000},"page":"645-651","source":"Crossref","is-referenced-by-count":8,"title":["Is <scp>ABO<\/scp> mismatch another risk factor for allogeneic hematopoietic stem cell transplantation in pediatric thalassemic patients?"],"prefix":"10.1111","volume":"19","author":[{"given":"Didem","family":"Atay","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology &amp; Bone Marrow Transplantation Unit Faculty of Medicine Atakent Hospital Ac\u0131badem University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Erbey","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology &amp; Bone Marrow Transplantation Unit Faculty of Medicine Atakent Hospital Ac\u0131badem University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Akcay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology &amp; Bone Marrow Transplantation Unit Faculty of Medicine Atakent Hospital Ac\u0131badem University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulyuz","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology &amp; Bone Marrow Transplantation Unit Faculty of Medicine Atakent Hospital Ac\u0131badem University Istanbul 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