{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:26:02Z","timestamp":1787610362008,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Donor\u2010specific anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antibodies (<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>) causing <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content> are responsible for a high proportion of long\u2010term graft failures after <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content>. We studied the prevalence of <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> children biopsied for creeping Cr, its relationship with <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>, and patient and graft survival according to histopathology. Between 2008 and 2013, 92 children were biopsied at a median of 38\u00a0months post\u2010<jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content>. At biopsy, the prevalence of <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> was 49% and C4d 70%. <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content> rate was 45%, higher in adolescents (60%). Most frequent diagnoses were <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content> (72%) and interstitial fibrosis with tubular atrophy (<jats:styled-content style=\"fixed-case\">IFTA<\/jats:styled-content>) (28%). Forty\u2010five of 66 patients with <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content> (68%) had detectable <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>. Twenty\u2010one <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\u2010negative patients with <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content> had histological damage (<jats:styled-content style=\"fixed-case\">IFTA<\/jats:styled-content>\u00a0+\u00a0C4d positivity). C4d was detected in 64 of 66 biopsies with <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>. Recipients with <jats:styled-content style=\"fixed-case\">IFTA<\/jats:styled-content> alone had neither C4d, nor detectable <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>, and were adherent. Graft survival at five\u00a0yr was 89% in patients with <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>, 79% in those with <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">TCMR<\/jats:styled-content> Banff I, 33% in those with <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">TCMR<\/jats:styled-content> Banff <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and 96% in those with <jats:styled-content style=\"fixed-case\">IFTA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">ABMR<\/jats:styled-content> and complement activation were frequent in children biopsied for creeping Cr. Recipients with <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> were more likely to be non\u2010adherent and have <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">TCMR<\/jats:styled-content> and worse graft survival.<\/jats:p>","DOI":"10.1111\/petr.12556","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T08:53:19Z","timestamp":1437727999000},"page":"684-690","source":"Crossref","is-referenced-by-count":9,"title":["Donor\u2010specific anti\u2010<scp>HLA<\/scp> antibodies in pediatric renal transplant recipients with creeping creatinine: Prevalence, histological correlations, and impact on patient and graft survival"],"prefix":"10.1111","volume":"19","author":[{"given":"Marta Lidia","family":"Monteverde","sequence":"first","affiliation":[{"name":"Department of Nephrology Hospital JP. Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital JP. Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital JP. Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia Yanina","family":"Marcos","sequence":"additional","affiliation":[{"name":"Department of Hemotherapy and Histocompatibility Hospital JP. Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Padros","sequence":"additional","affiliation":[{"name":"Department of Histocompatibility Fundaci\u00f3n Favaloro Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziomara","family":"Balbarrey","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital JP. Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Briones","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital JP. 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