{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:13:35Z","timestamp":1772237615258,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune\u2010mediated bowel disease has been reported after pediatric heart transplantation. Recognition and treatment of these patients has been difficult. We describe a patient who responded to steroids and basiliximab therapy after an inflammatory process secondary to abnormal T\u2010cell activation. Our patient is a 28\u2010month\u2010old female who received a heart transplant at five\u00a0wk of age. At 24\u00a0months post\u2010transplant, she developed fever and bloody stools. Initial investigations were significant for an elevated <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> (&gt;120) and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (15.2). Symptoms persisted despite bowel rest and mycophenolate discontinuation. Endoscopic evaluation revealed discontinuous ulcerative disease involving esophagus, terminal ileum, right and left colon, necessitating extensive bowel resection. She had additional airway inflammation leading to a <jats:styled-content style=\"fixed-case\">TEF<\/jats:styled-content> at the site of esophageal ulceration, requiring tracheostomy. Immune evaluation revealed autoimmune dysregulation that responded to parenteral methylprednisolone. Chronic basiliximab therapy allowed for successful weaning of steroids with sustained remission. She has been transitioned to sirolimus and tacrolimus maintenance immunosuppression with plans to discontinue basiliximab once off steroids. In conclusion, bowel disease in the setting of pediatric heart transplantation can be severe and refractory to traditional treatment methods. Tailoring immune therapy to activated T cells can result in remission. Basiliximab therapy was used in our patient to maintain steroid\u2010induced remission, but long\u2010term complications of this disease process are unknown.<\/jats:p>","DOI":"10.1111\/petr.12584","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T05:29:15Z","timestamp":1442381355000},"source":"Crossref","is-referenced-by-count":2,"title":["Basiliximab treatment for autoimmune bowel disease in a pediatric heart transplant patient"],"prefix":"10.1111","volume":"19","author":[{"given":"K.","family":"Puri","sequence":"first","affiliation":[{"name":"The Heart Institute Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kocoshis","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Risma","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Perez","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hart","sequence":"additional","affiliation":[{"name":"Otolaryngology Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chin","sequence":"additional","affiliation":[{"name":"The Heart Institute Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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R.","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology CS Mott Children's Hospital Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Castleberry","sequence":"additional","affiliation":[{"name":"The Heart Institute Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00383-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.07.061"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90283-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12205"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i13.3525"},{"key":"e_1_2_7_8_1","first-page":"279","article-title":"A case series of transplant recipients who despite immunosuppression developed inflammatory bowel disease","volume":"92","author":"Riley TR","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.06.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.10.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000147735.19342.DE"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-341396"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.12.015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03771.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1962"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-3038.2003.00130.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182662233"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01082.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02024.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.157297"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20395"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.02.024"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1263"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12584","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:55:56Z","timestamp":1695538556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,16]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/petr.12584"],"URL":"https:\/\/doi.org\/10.1111\/petr.12584","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,16]]}}}