{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:27:58Z","timestamp":1783589278325,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,20]],"date-time":"2015-09-20T00:00:00Z","timestamp":1442707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Data were collected of children admitted with\n                    <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>\n                    to 16\n                    <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                    pediatric liver transplant centers from 2008 to 2013 using the\n                    <jats:styled-content style=\"fixed-case\">PHIS<\/jats:styled-content>\n                    for a retrospective analysis of PALF trends. Patient data linked to the principal diagnosis code for acute necrosis of the liver (570.00) were analyzed for the following: demographics, regional differences, changes over time, pharmaceutical trends, procedural trends, associated diagnoses, and patient outcomes. In 52.5% of 583 patients who met the selection criteria for\n                    <jats:styled-content style=\"fixed-case\">PALF<\/jats:styled-content>\n                    , the etiology remained undetermined. Acetaminophen toxicity (18.7%) was the most common identifiable etiology, and hepatic encephalopathy (38.6%) was the most common complication. Mortality was lower than previously reported; 95.4% survived and 73.2% survived without a liver transplant. Acute respiratory failure (\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    = 3.4, p = 0.035), acute kidney injury (\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    = 3.6, p = 0.003), and cerebral edema (\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    = 3.6, p = 0.02) were independently associated with increased risk of mortality. The use of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine in non\u2010acetaminophen\u2010related\n                    <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>\n                    , the use of intracranial pressure monitoring, and the proportion of sepsis decreased significantly during the study period. The\n                    <jats:styled-content style=\"fixed-case\">PHIS<\/jats:styled-content>\n                    database can be a useful tool to study the future trends of\n                    <jats:styled-content style=\"fixed-case\">PALF<\/jats:styled-content>\n                    patients.\n                  <\/jats:p>","DOI":"10.1111\/petr.12596","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T07:01:26Z","timestamp":1442818886000},"page":"888-895","source":"Crossref","is-referenced-by-count":54,"title":["Use of\n                    <scp>P<\/scp>\n                    ediatric\n                    <scp>H<\/scp>\n                    ealth\n                    <scp>I<\/scp>\n                    nformation\n                    <scp>S<\/scp>\n                    ystem database to study the trends in the incidence, management, etiology, and outcomes due to pediatric acute liver failure in the\n                    <scp>U<\/scp>\n                    nited\n                    <scp>S<\/scp>\n                    tates from 2008 to 2013"],"prefix":"10.1111","volume":"19","author":[{"given":"Sakil","family":"Kulkarni","sequence":"first","affiliation":[{"name":"Department of Medical Education Miami Children's Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Medical Education Miami Children's Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren","family":"Pichardo","sequence":"additional","affiliation":[{"name":"Department of Medical Education Miami Children's Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Medical Education Miami Children's Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Department of Quality and Safety Miami Children's Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Beck\u2010Sague","sequence":"additional","affiliation":[{"name":"Robert Stempel College of Public Health and Social Work Florida International University Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani","family":"Gereige","sequence":"additional","affiliation":[{"name":"Department of Medical Education Miami Children's Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Miami Children's Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.11.57"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.051"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-12-200212170-00007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.119989"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.09.058"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-014-3513-y"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24930"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.02.062"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/15748863113086660051"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/142625"},{"key":"e_1_2_7_12_1","first-page":"22","article-title":"Achieving data quality. 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