{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:37:02Z","timestamp":1784194622590,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> is a serious complication of both solid organ and <jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content>. This study assessed whether <jats:sup>18<\/jats:sup>F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>, when added to CT scan, had additional value in the initial evaluation of PTLD in pediatric patients and whether PET\/CT at baseline can reliably guide biopsy. This retrospective study evaluated 34 consecutive pediatric patients (14 female), aged 3.5\u201317.0\u00a0yr (mean age: 9.9\u00a0yr, s.d.: 4.9\u00a0yr), who had undergone <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT from May 2007 to December 2014 at initial diagnosis of PTLD following heart (n\u00a0=\u00a013), lung (n\u00a0=\u00a08), kidney (n\u00a0=\u00a04), liver (n\u00a0=\u00a03), liver and bowel (n\u00a0=\u00a03), and bone marrow (n\u00a0=\u00a03) transplantation. PTLD was diagnosed histopathologically in 33 patients and was based on clinical findings, elevated EBV, and imaging and follow\u2010up results in one patient. On lesion\u2010based analysis, <jats:sup>18<\/jats:sup>F\u2010FDG PET showed more lesions than conventional CT scan (168 vs. 134), but CT revealed 22 lesions negative on PET. On per patient analysis, PET detected more lesions in 13 patients, CT identified more abnormalities in seven, and both showed the same number of lesions in 14. Adding <jats:sup>18<\/jats:sup>F\u2010FDG PET to CT scans upstaged the disease in seven patients (20.5%). A combination of <jats:sup>18<\/jats:sup>F\u2010FDG PET and CT was also useful in guiding biopsy, being positive in 36 of 39 samples (92.3%). These findings indicated that <jats:sup>18<\/jats:sup>F\u2010FDG PET and CT are complementary at initial staging of pediatric PTLD and that <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT scanning can guide biopsies.<\/jats:p>","DOI":"10.1111\/petr.12611","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T09:13:46Z","timestamp":1446196426000},"page":"932-939","source":"Crossref","is-referenced-by-count":32,"title":["The value of <sup>18<\/sup>F\u2010<scp>FDG PET<\/scp> in pediatric patients with post\u2010transplant lymphoproliferative disorder at initial diagnosis"],"prefix":"10.1111","volume":"19","author":[{"given":"R.","family":"Vali","sequence":"first","affiliation":[{"name":"Diagnostic Imaging Department The Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Punnett","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bajno","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department The Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Moineddin","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Shammas","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department The Hospital for Sick Children University of Toronto Toronto ON 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