{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T14:26:48Z","timestamp":1725632808020},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> is an autosomal recessive disorder characterized by small stature and renal abnormalities. <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> can lead to progressive bone marrow failure, myelodysplastic syndrome, or acute leukemia. Using a multidisciplinary team approach, we managed a 3\u2010yr\u2010old boy with <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> who simultaneously developed renal and hematopoietic failure. Because renal function was insufficient to support the conditioning regimen for <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>, we performed a deceased donor renal transplant in December 2012 prior to <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> with the known risk of graft\u2010versus\u2010graft rejection of the donor kidney. Seven months later he underwent allogeneic <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. He obtained myeloid engraftment on day +11 and peripheral blood chimerism demonstrated all donor by day +21. He developed asymptomatic <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> reactivation and despite antirejection medications, mild skin graft\u2010versus\u2010host disease. He has maintained excellent renal function and remains transfusion independent with full hematopoietic recovery. He has not experienced any renal rejection episodes nor developed donor\u2010specific antibodies toward his renal donor. Peripheral blood chimerism remains completely <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> donor. He is clinically well, now greater than two and a half yr after renal transplant and two yr after <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. The continuing close collaboration between the Pediatric Nephrology and Bone Marrow Transplant teams is a major factor in this successful outcome.<\/jats:p>","DOI":"10.1111\/petr.12619","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T12:51:38Z","timestamp":1445345498000},"page":"146-150","source":"Crossref","is-referenced-by-count":6,"title":["Sequential renal and bone marrow transplants in a child with Fanconi anemia"],"prefix":"10.1111","volume":"20","author":[{"given":"Carol L.","family":"Vincent","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of North Carolina Chapel Hill NC USA"},{"name":"Department of Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Primack","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of North Carolina Chapel Hill NC USA"},{"name":"Department of Medicine 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