{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:47:42Z","timestamp":1768286862745,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T00:00:00Z","timestamp":1447459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>POI<\/jats:styled-content> is a relevant late complication after HSCT<\/jats:styled-content> and occurring more frequently after MAC<\/jats:styled-content> than after RIC<\/jats:styled-content> regimens. Reports on the frequency of POI<\/jats:styled-content> after RIC<\/jats:styled-content> in a large pediatric and adolescent population are lacking. In this study, we describe a girl affected by CML<\/jats:styled-content> diagnosed at the age of 15 yr and treated with oncarbide and interferon followed by imatinib and dasatinib. She had two pregnancies shortly after RIC<\/jats:styled-content> performed according to the CML<\/jats:styled-content>\u2010SCT<\/jats:styled-content> I\u2010BFM<\/jats:styled-content> protocol including TT, FLU, and MEL. Hypergonadotropic hypogonadism occurred four months after HSCT<\/jats:styled-content>; menstruations resumed regularly six months after HSCT<\/jats:styled-content>. Eight and 20 months after HSCT<\/jats:styled-content>, the patient became pregnant and then delivered, respectively, two babies at term by cesarean section. Both newborns had no neonatal complications. Donor chimerism at time of two pregnancies and five yr after transplantation demonstrated complete donor engraftment. These findings suggest that I\u2010BFM CML<\/jats:styled-content>\u2010SCT<\/jats:styled-content> protocol could be a promising treatment option for adolescents or young adults with CML<\/jats:styled-content> eligible for HSCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12630","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T07:22:42Z","timestamp":1447485762000},"page":"158-161","source":"Crossref","is-referenced-by-count":5,"title":["Two pregnancies shortly after transplantation with reduced intensity conditioning in chronic myeloid leukemia"],"prefix":"10.1111","volume":"20","author":[{"given":"Maura","family":"Faraci","sequence":"first","affiliation":[{"name":"Stem Cell Transplantation Unit \u2013 Haematology\u2010Oncology Department G. Gaslini Children's Research Institute Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Matthes\u2010Martin","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation Unit St Anna Children's Hospital Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Lanino","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation Unit \u2013 Haematology\u2010Oncology Department G. Gaslini Children's Research Institute Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Morreale","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation Unit \u2013 Haematology\u2010Oncology Department G. Gaslini Children's Research Institute Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation Unit \u2013 Haematology\u2010Oncology Department G. Gaslini Children's Research Institute Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Giardino","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation Unit \u2013 Haematology\u2010Oncology Department G. Gaslini Children's Research Institute Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Micalizzi","sequence":"additional","affiliation":[{"name":"Haematology Unit \u2013 Haematology\u2010Oncology Department G. Gaslini Children's Research Institute Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Balduzzi","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica Universit\u00e0 degli Studi di Milano Bicocca Ospedale San Gerardo Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.7114"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6557"},{"key":"e_1_2_6_4_1","first-page":"315","article-title":"Principal long\u2010term adverse effects of imatinib in patients with chronic myeloid leukemia in chronic phase","volume":"2","author":"Mughal TI","year":"2010","journal-title":"Biologics"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501569"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0707841"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2013.860115"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.05.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1182\/blood.V87.7.3045.bloodjournal8773045","article-title":"Pregnancies following high dose cyclophosphamide with or without high dose busulfan or total\u2010body irradiation and bone marrow transplantation","volume":"87","author":"Sanders JE","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10773"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.5.813"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.07.009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000640"},{"key":"e_1_2_6_14_1","first-page":"1725","article-title":"Low prevalence of premature ovarian failure in women given reduced\u2010intensity conditioning regimens for hematopoietic stem\u2010cell transplantation","volume":"90","author":"Cheng YC","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.416"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.14"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12630","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:11:47Z","timestamp":1695503507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,14]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/petr.12630"],"URL":"https:\/\/doi.org\/10.1111\/petr.12630","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,14]]}}}