{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:18:30Z","timestamp":1781770710491,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several centers have examined the implementation of immunosuppression protocols that minimize steroid exposure. This study retrospectively examined cardiovascular risk factors in 70 pediatric renal transplant recipients on steroid avoidance\u2010based immunosuppression over three yr compared to matched pediatric patients maintained on chronic corticosteroids. Although higher rates of acute rejection were noted in the steroid\u2010avoidant group (22% vs. 16%, p = 0.034), graft function was similar (67 + 10 mL\/min\/1.73 m<jats:sup>2<\/jats:sup> vs. 72 + 12 mL\/min\/1.73 m<jats:sup>2<\/jats:sup>) (p = 0.053). The steroid\u2010avoidant group demonstrated improved growth (height <jats:italic>z<\/jats:italic>\u2010score \u22120.41 + 5.9 vs. \u22121.1 + 0.041) with a decrease in the prevalence of obesity (24% vs. 34%, p = 0.021). Indexed systolic blood pressures were lower beginning at six months post\u2010transplant in the steroid\u2010avoidant group (1.21 + 0.15 vs. 1.51 + 0.22, p = 0.020). Indexed diastolic blood pressures were lower beginning at 12 months post\u2010transplant (0.91 + 0.11 vs. 1.12 + 0.18, p = 0.037). Differences in total serum cholesterol values and serum glucose values were not statistically significant. Beginning at 12 months, a statistically significant decrease in left ventricular mass index (39.2 + 11.3 vs. 49.4 + 14.5, p = 0.014) was noted in patients on steroid\u2010avoidant immunosuppression, which corresponded to a significant decrease in the prevalence of left ventricular hypertrophy in these patients by two yr post\u2010transplant (35% vs. 48%, p = 0.012). Systolic blood pressure and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> were independent predictors of left ventricular hypertrophy.<\/jats:p>","DOI":"10.1111\/petr.12633","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T11:52:40Z","timestamp":1448020360000},"page":"59-67","source":"Crossref","is-referenced-by-count":15,"title":["Improved cardiovascular risk factors in pediatric renal transplant recipients on steroid avoidance immunosuppression: A study of the Midwest Pediatric Nephrology Consortium"],"prefix":"10.1111","volume":"20","author":[{"suffix":"Jr.","given":"Donald J.","family":"Weaver","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Pediatrics Levine Children's Hospital at Carolinas Medical Center Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Selewski","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Pediatrics C.S. 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