{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:11:39Z","timestamp":1781763099454,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000423"],"award-info":[{"award-number":["UL1TR000423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of donor\u2013recipient sex matching on long\u2010term survival in pediatric heart transplantation is not well known. Adult data have shown worse survival when male recipients receive a sex\u2010mismatched heart, with conflicting results in female recipients. We analyzed 5795 heart transplant recipients \u226418 yr in the Scientific Registry of Transplant Recipients (1990\u20132012). Recipients were stratified based on donor and recipient sex, creating four groups: MM (N = 1888), FM (N = 1384), FF (N = 1082), and MF (N = 1441). Males receiving sex\u2010matched donor hearts had increased unadjusted allograft survival at five yr (73.2 vs. 71%, p = 0.01). However, this survival advantage disappeared with longer follow\u2010up and when adjusted for additional risk factors by multivariable Cox regression analysis. In contrast, for females, receiving a sex\u2010mismatched heart was associated with an 18% higher risk of allograft loss over time compared to receiving a sex\u2010matched heart (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.18, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.00\u20131.38) and a 26% higher risk compared to sex\u2010matched male recipients (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.26, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.10\u20131.45). Females who receive a heart from a male donor appear to have a distinct long\u2010term survival disadvantage compared to all other groups.<\/jats:p>","DOI":"10.1111\/petr.12649","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T10:33:09Z","timestamp":1450780389000},"page":"249-255","source":"Crossref","is-referenced-by-count":19,"title":["Impact of donor\u2013recipient sex match on long\u2010term survival after heart transplantation in children: An analysis of 5797 pediatric heart transplants"],"prefix":"10.1111","volume":"20","author":[{"given":"Mariska","family":"Kemna","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Albers","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda C.","family":"Bradford","sequence":"additional","affiliation":[{"name":"Core for Biomedical Statistics Seattle Children's Hospital Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Law","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Columbia University College of Physicians and Surgeons New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester","family":"Permut","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Mike","family":"McMullan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk","family":"Law","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.03.018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.11.456"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)01105-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.844183"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000030078.74889.69"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.01.007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.206"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12451"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2013.01.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/5.1.32"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.03.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.014"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.09.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318163feaf"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.889323"},{"key":"e_1_2_10_20_1","first-page":"1926","article-title":"Does donor and recipient sex influence the development of cardiac allograft vasculopathy?","volume":"27","author":"Mehra M","year":"1995","journal-title":"Transplant Proc"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00282-8"},{"key":"e_1_2_10_22_1","first-page":"419","article-title":"Increased cardiac allograft rejection in female heart transplant recipients","volume":"7","author":"Crandall BG","year":"1988","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284141"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8514-3"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32832d399c"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31817352b9"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.09.007"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)90281-L"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12649","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T01:31:45Z","timestamp":1696037505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,22]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/petr.12649"],"URL":"https:\/\/doi.org\/10.1111\/petr.12649","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,22]]}}}