{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T17:52:39Z","timestamp":1766339559306},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiovascular diseases induce long\u2010term morbidity and mortality of adult <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients. The aim of this retrospective study was to assess <jats:styled-content style=\"fixed-case\">CVRF<\/jats:styled-content>, lipid abnormalities, and atherosclerosis (appraised by c\u2010<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>), more than 10 yr after pediatric <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. Thirty\u2010one children who underwent <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> between December 1990 and December 2000 were included. Median age at <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> was 14 months (range 4\u201364), and median follow\u2010up after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> was 11.9 yr (range 9.0\u201317.3). In our cohort, obesity (9.7%) and treated hypertension (9.7%) were rare. None of the patients was smoker or diabetic. High <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> were both observed in 6.5% of the patients. The mean c\u2010<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> for male patients was 1.22 \u00b1 1.55 and 1.58 \u00b1 1.23 mm in female patients. Seven patients (22%) had a mean c\u2010<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> above +2 s.d. Values below the 5th percentile were noted for <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010cholesterol (58.1%), <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010cholesterol (25.8%), apolipoprotein B (40%), and apolipoprotein A1 (20%). <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010cholesterol and apolipoprotein B levels were significantly lower in patients treated by tacrolimus in comparison with CsA (p &lt; 0.05). In conclusion, our results suggest that pediatric <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> patients do not present significant <jats:styled-content style=\"fixed-case\">CVRF<\/jats:styled-content>; moreover, instead of hyperlipidemia, hypocholesterolemia (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C) is frequent and immunosuppressive therapy is probably the cause.<\/jats:p>","DOI":"10.1111\/petr.12664","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T05:49:45Z","timestamp":1452491385000},"page":"241-248","source":"Crossref","is-referenced-by-count":10,"title":["Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients"],"prefix":"10.1111","volume":"20","author":[{"given":"Emilie","family":"Roblin","sequence":"first","affiliation":[{"name":"Service d'H\u00e9patologie Gastroent\u00e9rologie et Nutrition p\u00e9diatriques H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Dumortier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Transplantation h\u00e9patique H\u00f4pital Edouard Herriot Hospices Civils de Lyon Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"UF Dyslipid\u00e9mies Cardiobiologie D\u00e9partement de Biochimie et de Biologie Mol\u00e9culaire du GHE Laboratoire de Biologie M\u00e9dicale Multi Sites Hospices Civils de Lyon Lyon France"},{"name":"INSERM U1060, INSA de Lyon, INRA U1235 Univ Lyon\u20101 Universit\u00e9 de Lyon Villeurbanne Oullins France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Collardeau\u2010Frachon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1 Lyon France"},{"name":"Service de Pathologie Groupement hospitalier Est Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Sassolas","sequence":"additional","affiliation":[{"name":"INSERM U1060, INSA de Lyon, INRA U1235 Univ Lyon\u20101 Universit\u00e9 de Lyon Villeurbanne Oullins France"},{"name":"Service de Pathologie Groupement hospitalier Est Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00ebl","family":"Peretti","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie Gastroent\u00e9rologie et Nutrition p\u00e9diatriques H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant Hospices Civils de Lyon Bron France"},{"name":"Service de Pathologie Groupement hospitalier Est Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Serusclat","sequence":"additional","affiliation":[{"name":"Service d'Imagerie H\u00f4pital Cardiovasculaire et pneumologique Louis Pradel Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Rivet","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie Gastroent\u00e9rologie et Nutrition p\u00e9diatriques H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Boillot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Transplantation h\u00e9patique H\u00f4pital Edouard Herriot Hospices Civils de Lyon Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Lachaux","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie Gastroent\u00e9rologie et Nutrition p\u00e9diatriques H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant Hospices Civils de Lyon Bron France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200203270-00012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199509000-00008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.68.9.260"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2002.tb00107.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2005.00174.x"},{"key":"e_1_2_8_7_1","first-page":"1057","article-title":"Metabolic complications after liver transplantation. 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