{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:54:49Z","timestamp":1760100889521},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["27\u20101"],"award-info":[{"award-number":["27\u20101"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010I donors requires preconditioning regimens to prevent postoperative catastrophic <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content> is known to cause myelosuppression leading to a reduction in the number and function of lymphocytes. We investigated this chemotherapy\u2010induced myelosuppression in <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content> patients listed for <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010I donors with reference to the kinetics of B, T cells, and anti\u2010<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> blood type isoagglutinin titers. Between 2005 and 2015, of the 319 patients who underwent <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> at our institute, 12 were indicated for unresectable <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content>. Three patients with unresectable <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content> who underwent <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010I donors are included in this study. Immunosuppression consisted of a standard regime of tacrolimus and low\u2010dose steroids as in <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> compatible\/identical <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>. No additional preoperative therapies for B\u2010cell depletion were used. Absolute lymphocyte counts, lymphocyte subsets (including <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20+ B cells, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3+<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3+<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells), and anti\u2010<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> blood type isoagglutinin titers were measured before <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> and postoperatively. The median age at diagnosis was 19 months (range, 3\u201331 months). The median follow\u2010up was seven months (range, 6\u201315 months). The median interval from the last <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> was 33 days (range, 25\u201352 days). The median interval from <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> to adjuvant chemotherapy was 28 days (range, 22\u201336 days). The counts of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20+ B cells before <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> were depleted to median 5 cells\/mm<jats:sup>3<\/jats:sup> (range, 0\u20136 cells\/mm<jats:sup>3<\/jats:sup>). There was a transient rebound in the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20+ B cell counts on day seven (maximum of 82 cells\/mm<jats:sup>3<\/jats:sup>) followed by a decline starting at 14 days after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> that was sustained for the duration of adjuvant chemotherapy. Anti\u2010<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> blood type isoagglutinin titers were lowered to between 1:1 and 1:16 before <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> and remained low for the duration of follow\u2010up in this study. All of the three patients remained in good health without either acute cellular or AMR after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>. The B\u2010cell depletion that occurs after cisplatin\u2010based chemotherapy for <jats:styled-content style=\"fixed-case\">HBL<\/jats:styled-content> may help accomplish safe <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010I <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> in children without the use of additional conditioning regimens for prevention of <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12675","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T04:41:00Z","timestamp":1458880860000},"page":"401-407","source":"Crossref","is-referenced-by-count":3,"title":["Chemotherapy\u2010induced B\u2010cell depletion in hepatoblastoma patients undergoing <scp>ABO<\/scp>\u2010incompatible living donor liver transplantation"],"prefix":"10.1111","volume":"20","author":[{"given":"Hiroyuki","family":"Kanazawa","sequence":"first","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinari","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidyadhar Padmakar","family":"Mali","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tri Hening","family":"Rahayatri","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Uchida","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seisuke","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimikazu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mureo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Transplantation Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000042"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12357"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01003.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12520"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12445"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-007-1298-2"},{"key":"e_1_2_9_8_1","first-page":"489","article-title":"Antibody\u2010mediated rejection of human orthotopic liver allografts. A study of liver transplantation across ABO blood group barriers","volume":"132","author":"Demetris AJ","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92082-S"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200211150-00001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000082723.02477.87"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12194"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200210270-00020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21928"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20652"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000110295.88926.5C"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21280"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2006.00296.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0361-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70272-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2708-0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.22.3819"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000046"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/383054"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1974.tb04576.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11464.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12276"},{"key":"e_1_2_9_29_1","first-page":"125","article-title":"Peripheral blood lymphocyte subsets in healthy Turkish children","volume":"46","author":"Ikinciogullari A","year":"2004","journal-title":"Turk J Pediatr"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000112934.12622.2B"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.10.3700"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.02.045"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318177793e"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1582"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.03027.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.020"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12675","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:02:12Z","timestamp":1696201332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,24]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/petr.12675"],"URL":"https:\/\/doi.org\/10.1111\/petr.12675","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,24]]}}}