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Similarly, chronic renal allograft injury (<jats:styled-content style=\"fixed-case\">CRAI<\/jats:styled-content>) is characterized by vascular injury and declining allograft function in transplant <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. We hypothesized that circulating <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content> factors could serve as non\u2010invasive biomarkers of <jats:styled-content style=\"fixed-case\">CRAI<\/jats:styled-content>. We conducted a cross\u2010sectional, multicenter case\u2013control study. Cases (n = 31) had transplant function &gt;20 mL\/min\/1.73 m<jats:sup>2<\/jats:sup> and biopsy\u2010proven <jats:styled-content style=\"fixed-case\">CRAI<\/jats:styled-content>. Controls (n = 31) had transplant function &gt;90 mL\/min\/1.73 m<jats:sup>2<\/jats:sup> and\/or a biopsy with no detectable abnormality in the previous six months. We measured plasma <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content> factors at a single time point using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Median (range) <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 levels were over twofold higher in <jats:styled-content style=\"fixed-case\">CRAI<\/jats:styled-content> vs. controls [106 (10\u2013475) pg\/mL vs. 45 (8\u201391) pg\/mL; p &lt; 0.001]. <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 levels were inversely correlated with transplant function (r<jats:sup>2<\/jats:sup> = \u22120.617, p &lt; 0.001). Higher <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 levels were associated with increased odds of biopsy\u2010proven <jats:styled-content style=\"fixed-case\">CRAI<\/jats:styled-content> after adjusting for transplant function, clinical, and demographic factors [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.43 (1.23, 1.67)]. Relationships between additional <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content> factors and <jats:styled-content style=\"fixed-case\">CRAI<\/jats:styled-content> were attenuated in multivariable models. Higher <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 levels were independently associated with biopsy\u2010proven <jats:styled-content style=\"fixed-case\">CRAI<\/jats:styled-content> in children.<\/jats:p>","DOI":"10.1111\/petr.12682","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T08:25:52Z","timestamp":1455611152000},"page":"378-387","source":"Crossref","is-referenced-by-count":4,"title":["Fibroblast growth factor\u201023 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-6178","authenticated-orcid":false,"given":"Michael E.","family":"Seifert","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology Department of Pediatrics Southern Illinois University Springfield IL USA"},{"name":"Department of Pediatrics Washington University St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isa F.","family":"Ashoor","sequence":"additional","affiliation":[{"name":"Division of Nephrology Children's Hospital of New Orleans New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myra L.","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West Virginia University Charleston WV USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aftab S.","family":"Chishti","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension and Renal Transplantation University of Kentucky Lexington KY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis J.","family":"Dietzen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie S.","family":"Gipson","sequence":"additional","affiliation":[{"name":"Division of Nephrology C.S. Mott Children's Hospital and University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halima S.","family":"Janjua","sequence":"additional","affiliation":[{"name":"Center for Pediatric Nephrology Cleveland Clinic Children's Hospital and Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Selewski","sequence":"additional","affiliation":[{"name":"Division of Nephrology C.S. 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