{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T08:06:12Z","timestamp":1746000372146},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the pediatric population, little is known on <jats:italic>de novo <\/jats:italic><jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> development, its impact on graft function, and association with suboptimal <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>. We assessed the prevalence of <jats:italic>de novo <\/jats:italic><jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> in the Vienna cohort of 40 renal transplanted children and adolescents and prospectively followed its association with clinical parameters, graft function, and proteinuria for one yr. At the cross\u2010sectional analysis (median post\u2010transplant time of five yr), 17% of the patients had developed <jats:italic>de novo <\/jats:italic><jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>. All <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010Ab were anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> antibodies and persisted in 85% of the cases until the follow\u2010up screening performed within one yr. Basic clinical and laboratory parameters did not differ between <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\u2010negative and <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\u2010positive patients at the time of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010Ab screening. Suboptimal <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> due to reduced medication or non\u2010adherence could not be proven in <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\u2010positive patients. The changes in eGFR did not differ during the prospective study period, but there was a significantly higher proteinuria in the <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\u2010positive patients during the follow\u2010up. Our data demonstrate an overall prevalence of 17% of <jats:italic>de novo <\/jats:italic><jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> in a pediatric renal transplant cohort. During 12 months of prospective follow\u2010up time, we could demonstrate a significant impact of <jats:italic>de novo <\/jats:italic><jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> presence on proteinuria.<\/jats:p>","DOI":"10.1111\/petr.12707","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T05:04:07Z","timestamp":1461042247000},"page":"507-514","source":"Crossref","is-referenced-by-count":11,"title":["Donor\u2010specific <scp>HLA<\/scp> antibodies and graft function in kidney\u2010transplanted children \u2013 the Vienna cohort"],"prefix":"10.1111","volume":"20","author":[{"given":"Krisztina","family":"Rusai","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna, Austria Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Dworak","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna, Austria Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Potemkina","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna, Austria Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gottfried","family":"Fischer","sequence":"additional","affiliation":[{"name":"University Clinic for Blood Group Serology and Transfusion Medicine Medical University Vienna, Austria Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Csaicsich","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna, Austria Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Arbeiter","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent 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