{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:52:47Z","timestamp":1791395567921,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5R25CA23944"],"award-info":[{"award-number":["5R25CA23944"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little information is available about survival of high\u2010risk pediatric neuroblastoma patients in developing countries. We aimed to assess survival among high\u2010risk pediatric neuroblastoma patients in La Plata, Argentina. Individuals eligible for our cohort were aged &lt;20 yr when diagnosed with high\u2010risk neuroblastoma and received cancer\u2010directed therapy including stem cell transplantation at Hospital de Ni\u00f1os Sor Maria Ludovica between February 1999 and February 2015. We estimated overall survival probabilities using an extended Kaplan\u2013Meier approach. Our study population comprised 39 high\u2010risk neuroblastoma patients, of whom 39% were aged &gt;4 yr at diagnosis, 54% were male, and 62% had adrenal neuroblastoma. We observed 18 deaths, and the median survival time of our study population was 1.7 yr. The five\u2010yr overall survival probability was 24% (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>: 10%, 41%). In contrast, five\u2010yr survival of high\u2010risk neuroblastoma patients ranges between 23% and 76% in developed countries. Survival among high\u2010risk neuroblastoma patients is generally poor regardless of geographic location, but our results illustrate dramatically worse survival for patients in a developing country. We speculate that the observed survival differences could be attenuated or eliminated with improvements in treatment and supportive care, but addressing these issues will require creative solutions because of resource limitations.<\/jats:p>","DOI":"10.1111\/petr.12731","type":"journal-article","created":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T04:36:13Z","timestamp":1464410173000},"page":"825-830","source":"Crossref","is-referenced-by-count":15,"title":["Survival of high\u2010risk pediatric neuroblastoma patients in a developing country"],"prefix":"10.1111","volume":"20","author":[{"given":"Joseph C.","family":"Easton","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN USA"},{"name":"School of Medicine Indiana University Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital de Ni\u00f1os Sor Maria Ludovica La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Asdahl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Conner","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Southern Mississippi Gulfport MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alcira B.","family":"Fynn","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital de Ni\u00f1os Sor Maria Ludovica La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital de Ni\u00f1os Sor Maria Ludovica La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-8990","authenticated-orcid":false,"given":"Rohit P.","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2014.09.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24433"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.08.001"},{"key":"e_1_2_9_5_1","article-title":"SEER Cancer Statistics Review, 1975\u20132012","author":"Howlander N","journal-title":"National Cancer Institute, Bethesda, MD. 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