{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T16:10:51Z","timestamp":1776615051098,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> is the only curative treatment for <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>. In this study, we estimated the number of Saudi patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> who are candidates for <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. We used the presence of overt stroke, recurrent ACS, and frequent severe pain crisis as indications for <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. We calculated the frequencies of these complications among a Saudi <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> cohort of 376 patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, 250 from <jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content> and 126 from Eastern (E) provinces. We found that 59 (23.6%) of <jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content> patients were transplant candidates compared to 22 (17.4%) from E province. It is estimated that about 61\u00a0000 patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> live in Saudi Arabia. Thus, the projected number of Saudi patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> who are candidates for <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> is 10\u00a0536 patients. Of those, 2148 are children. The burden of <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> centers in Saudi Arabia is substantial and is difficult currently to meet the demand. We recommend recruiting\/training more transplant physicians and nurses, expand current capacity of centers if feasible, and open new transplant centers to make <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> a practical therapeutic option for patients with severe <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> in Saudi Arabia.<\/jats:p>","DOI":"10.1111\/petr.12767","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T15:59:28Z","timestamp":1470153568000},"page":"831-835","source":"Crossref","is-referenced-by-count":13,"title":["Demands and challenges for patients with sickle\u2010cell disease requiring hematopoietic stem cell transplantation in Saudi Arabia"],"prefix":"10.1111","volume":"20","author":[{"given":"Abdulrahman","family":"Alsultan","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Sickle Cell Disease Research Center College of Medicine King Saud University  Riyadh Saudi Arabia"},{"name":"Department of Pediatric Hematology\/Oncology King Abdullah Specialist Children's Hospital  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasil","family":"Jastaniah","sequence":"additional","affiliation":[{"name":"King Abdulaziz Medical City  Jeddah Saudi Arabia"},{"name":"Department of Pediatrics College of Medicine Umm alQura University  Makkah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameera","family":"Al Afghani","sequence":"additional","affiliation":[{"name":"King Fahad Specialist Hospital  Dammam Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneer H.","family":"Al Bagshi","sequence":"additional","affiliation":[{"name":"Maternity and Children's Hospital  Hofuf Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaki","family":"Nasserullah","sequence":"additional","affiliation":[{"name":"Maternity &amp; Children's Hospital  Dammam Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Al\u2010Suliman","sequence":"additional","affiliation":[{"name":"King Fahad Hospital  Hofuf Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed K.","family":"Alabdulaali","sequence":"additional","affiliation":[{"name":"King Fahad Hospital  Hofuf Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,31]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1480","article-title":"The prevalence of sickle cell disease in Saudi children and adolescents. 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