{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T06:11:48Z","timestamp":1775369508775,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for PFIC type 1 is often complicated by postoperative diarrhea and recurrent graft steatosis. A 26\u2010month\u2010old female child with cholestatic jaundice, pruritus, diarrhea, and growth retardation revealed total bilirubin 9.1\u00a0mg\/dL, gamma\u2010glutamyl transpeptidase 64\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L, and TBA 295.8\u00a0\u03bcmol\/L. Genetic analysis confirmed <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>8B1 defects. A <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> (segment 2, 3 graft) from the heterozygous father was performed. Biliary diversion was performed by a 35\u2010cm jejunum conduit between the graft hepatic duct and the mid\u2010transverse colon. Stools became pigmented immediately. Follow\u2010up at 138\u00a0days revealed resolution of jaundice and pruritus and soft\u2010to\u2010hard stools (6\u20138 daily). Radioisotope hepato\u2010biliary scintigraphy (days 26, 68, and 139) confirmed unobstructed bile drainage into the colon (t<jats:sub>1\/2<\/jats:sub> 34, 27, and 19\u00a0minutes, respectively). Contrast meal follow\u2010through at day 62 confirmed the absence of any colo\u2010jejuno\u2010hepatic reflux. At 140\u00a0days, contrast follow\u2010through via the biliary stent revealed patent jejuno\u2010colonic anastomosis and satisfactory transit. Graft biopsy at <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, 138\u00a0days, and 9\u00a0months follow\u2010up revealed comparable grades of macrovesicular steatosis (&lt;20%). TIBD during <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> may be a clinically effective stoma\u2010free biliary diversion and may prevent recurrent graft steatosis following <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">PFIC<\/jats:styled-content> type 1.<\/jats:p>","DOI":"10.1111\/petr.12782","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T04:12:42Z","timestamp":1471493562000},"page":"981-986","source":"Crossref","is-referenced-by-count":33,"title":["Total internal biliary diversion during liver transplantation for type 1 progressive familial intrahepatic cholestasis: a novel approach"],"prefix":"10.1111","volume":"20","author":[{"given":"V. P.","family":"Mali","sequence":"first","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Uchida","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hirata","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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