{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:40Z","timestamp":1761630760663},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Optimal strategies to prevent cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) disease following pediatric solid organ transplantation remain controversial. The purpose of this study was to review the outcomes of a risk\u2010stratified strategy that uses a hybrid or prophylactic strategy for donor (D)+ recipient (R)\u2212 patients, a preemptive strategy for D+R+\/D\u2212R+, and clinical follow\u2010up alone for D\u2212R+ patients. A retrospective chart review was undertaken at the Stollery Children's Hospital in Edmonton, Alberta for pediatric solid organ transplants 2004 through 2010. Transplants were risk\u2010stratified according to D\/R <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> serostatus, organ group, and type of induction or rejection immunosuppression. The incidence of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>emia and <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> disease and adverse effects from prophylaxis were analyzed. The study included 197 recipients. <jats:styled-content style=\"fixed-case\">CMV DNA<\/jats:styled-content>emia was detected in 49 of 197 recipients (24.8%), and <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> disease occurred in eight of 197 (4%) of which all but one were D+R\u2212. All recovered. Seventeen of 142 recipients who received prophylaxis (12%) had hematologic toxicity. No other toxicities were identified. In conclusion, A risk\u2010stratified approach resulted in very low rates of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> disease with minimal adverse effects. Lowering the dosage rather than stopping antivirals in the face of neutropenia has the potential to further lower the rate of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.12786","type":"journal-article","created":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T04:22:50Z","timestamp":1472271770000},"page":"970-980","source":"Crossref","is-referenced-by-count":13,"title":["A risk\u2010stratified approach to cytomegalovirus prevention in pediatric solid organ transplant recipients"],"prefix":"10.1111","volume":"20","author":[{"given":"Sneha","family":"Suresh","sequence":"first","affiliation":[{"name":"Department of Pediatrics Stollery Children's Hospital and University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonita E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stollery Children's Hospital and University of 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