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A total of 90 children (aged &lt;20\u00a0years) who underwent <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> were evaluated to investigate the predictive factors associated with <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s. Twelve patients (13.3%) developed <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> (age range, 2\u201015\u00a0years). The symptoms of <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s were seizures, VD, and stupor. The median onset of <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s was 10\u00a0days (range, 5\u201030\u00a0days) post\u2010transplant. In the univariate analysis, higher recipient age at <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>, donor age and recipient's BW, lower actual GV\/SLV and <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> dosage\/BW, and higher mean T\u2010Bil and sodium level for 7\u00a0days after transplantation were independently significantly associated with <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s. Multivariate analysis showed that the T\u2010Bil level in the first week after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> was the only significant independent predictive factor for <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.588; 95% CI, 1.042\u20102.358; <jats:italic>P<\/jats:italic>=.031). In conclusion, <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s occurred most frequently in children over 5\u00a0years and were associated with hyperbilirubinemia for 7\u00a0days post\u2010transplant, regardless of <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> levels. The transplant team should refer to a neurologist to define the diagnosis and to collaborate to resolve the neurological problems.<\/jats:p>","DOI":"10.1111\/petr.12843","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T04:13:30Z","timestamp":1478060010000},"source":"Crossref","is-referenced-by-count":6,"title":["Early post\u2010transplant hyperbilirubinemia is a possible predictive factor for developing neurological complications in pediatric living donor liver transplant patients receiving tacrolimus"],"prefix":"10.1111","volume":"21","author":[{"given":"Kazushige","family":"Sato","sequence":"first","affiliation":[{"name":"Department of general medicine Tosendo Hospital  Wakuya Japan"},{"name":"Division of Advanced Surgical Science and Technology Graduate School of Medicine Tohoku University  Sendai 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