{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:37Z","timestamp":1789609117359,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> is a risk factor for graft failure after <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x. We studied impact of <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> in 22 children transplanted between 2008 and 2012 (11 isolated <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x, 10 liver inclusive Tx, and one modified multivisceral Tx). Three patients never developed <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>, but <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>s were found in seven in the pre\u2010Tx period and de novo post\u2010Tx in 19 children. Pathology revealed cellular rejection (15\/19), with vascular changes and C4d+. Patients were treated with <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> immunoglobulins, plasmapheresis, and steroids. Rescue therapy included antithymocyte globulins, rituximab, eculizumab, and bortezomib. Pathology and graft function normalized in 13 patients, graft loss occurred in two, and death in seven. At the end of the follow\u2010up, 15 children were alive (68%), 13 with functioning graft (59%). Prognosis factors for poor outcome after Tx were the presence of symptoms at <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> suspicion (<jats:italic>P<\/jats:italic> +.033). <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>s were often found following <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x, mostly de novo. Resistant <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> or severe <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> is still difficult to differentiate, with a high need for immunosuppression in both. <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>s may precede development of severe disease and pathology features on the graft: relationship and correlation need to be better investigated with larger groups before and after Tx.<\/jats:p>","DOI":"10.1111\/petr.12847","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T16:58:12Z","timestamp":1484326692000},"source":"Crossref","is-referenced-by-count":26,"title":["Impacts of donor\u2010specific anti\u2010HLA antibodies and antibody\u2010mediated rejection on outcomes after intestinal transplantation in children"],"prefix":"10.1111","volume":"21","author":[{"given":"L.\u2010M.","family":"Petit","sequence":"first","affiliation":[{"name":"Unit\u00e9 d'H\u00e9pato\u2010Gastroent\u00e9rologie et Nutrition P\u00e9diatriques H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneve Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rabant","sequence":"additional","affiliation":[{"name":"Service d'Anatomopathologie H\u00f4pital Necker Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Canioni","sequence":"additional","affiliation":[{"name":"Service d'Anatomopathologie H\u00f4pital Necker Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Suberbielle\u2010Boissel","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histocompatibilit\u00e9 H\u00f4pital Saint Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Goulet","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie et Nutrition P\u00e9diatriques H\u00f4pital Necker Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chardot","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Visc\u00e9rale P\u00e9diatrique H\u00f4pital Necker Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lacaille","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie et Nutrition P\u00e9diatriques H\u00f4pital Necker Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"www.intestinaltransplantregistry.org."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04237.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820000a1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182888df0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318229f752"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e3283533847"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12556"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.08.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.03.153"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.01.079"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03931.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.02.015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb02954.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182293d73"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00050.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12250"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009101065"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.6.783"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.30108.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.12.026"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02221.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000078"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03807.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.09.038"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.02.037"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01543.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182802f88"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000226078.94635.76"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:30:52Z","timestamp":1695040252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/petr.12847"],"URL":"https:\/\/doi.org\/10.1111\/petr.12847","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,13]]},"article-number":"e12847"}}