{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:03:52Z","timestamp":1788397432271,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T00:00:00Z","timestamp":1483142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005754","name":"Sahlgrenska Universitetssjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rate of PTLD can be reduced by weaned IS guided by monitoring of EBV <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>. In this single\u2010center retrospective case series study, we analyzed how reduction in IS influenced <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content> levels in whole blood and serum in 30 children during the first year after liver transplantation, and how these levels were related to symptoms putatively due to <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>. Primary and reactivated <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection was seen in 18 (60%) and eight patients (27%), respectively. Thirteen patients (42%) developed chronic high load the first year post\u2010transplant. IS was successfully discontinued in six patients the first year post\u2010transplant and in another two patients within 3\u00a0years. <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content> levels were reduced, but persisted long term in all the eight patients who had IS completely withdrawn. There was no case of <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>. In summary, <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> DNAemia and chronic high load were very common after pediatric liver transplantation. Liver graft tolerance facilitates radical reduction in IS treatment, which may prevent <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>, but <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content>emia may persist long term after discontinued IS.<\/jats:p>","DOI":"10.1111\/petr.12875","type":"journal-article","created":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T06:56:45Z","timestamp":1483167405000},"source":"Crossref","is-referenced-by-count":20,"title":["Epstein\u2010Barr virus <scp>DNA<\/scp> monitoring in serum and whole blood in pediatric liver transplant recipients who do or do not discontinue immunosuppressive therapy"],"prefix":"10.1111","volume":"21","author":[{"given":"C.","family":"Kullberg\u2010Lindh","sequence":"first","affiliation":[{"name":"Department of Pediatrics Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Saalman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Olausson","sequence":"additional","affiliation":[{"name":"Department of Surgery Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-9962","authenticated-orcid":false,"given":"G.","family":"Herlenius","sequence":"additional","affiliation":[{"name":"Department of Surgery Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lindh","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Institute of Biomedicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-010-9329-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/814973"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2009.01283.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23659"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2012.01608.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2001.003002079.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02080.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01360.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.03.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01396.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04217-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.09.033"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2008.00313.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00656.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.712-715.2000"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01389.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.09.020"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.00926.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2004.00129.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.2014"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2008.00765.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200108150-00016"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12301"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03928.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59411"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/MOT.0b013e3283636fd5","article-title":"Biomarkers of tolerance","volume":"18","author":"Gokmen R","year":"2013","journal-title":"Curr Opin Organ Transplant"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2012.01750.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02799.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.1999.01119.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.10.004"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12875","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:56:54Z","timestamp":1696201014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,31]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/petr.12875"],"URL":"https:\/\/doi.org\/10.1111\/petr.12875","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,31]]},"article-number":"e12875"}}