{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:48:45Z","timestamp":1773892125996,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>HSCT<\/jats:styled-content> is a curative treatment in TM<\/jats:styled-content>, but conditioning and immunosuppressive treatment may affect bone metabolism. In this retrospective study, we aimed to compare BMD<\/jats:styled-content>, vitamin D status, and growth in children with TM<\/jats:styled-content> who underwent HSCT<\/jats:styled-content> to those in children with TD TM<\/jats:styled-content>. Twenty\u2010three children with TM<\/jats:styled-content> who underwent HSCT<\/jats:styled-content> (mean age 7.1\u00a0years [1.03\u201014.7]) and 24 children with TD<\/jats:styled-content> thalassemia (mean age 9.8\u00a0years [1.6\u201014]) were recruited. Lumbar spine BMD<\/jats:styled-content> of TD<\/jats:styled-content> thalassemia patients was higher than those in patients who had HSCT<\/jats:styled-content> at both baseline and second\u2010year assessments (P<\/jats:italic>=.009, P<\/jats:italic><.001, respectively). However, BMD<\/jats:styled-content> Z scores or serum 25\u2010OH<\/jats:styled-content> vitamin D levels were not different in two groups. Being >10\u00a0years of age was a significant risk factor for low BMD<\/jats:styled-content>, height, and weight Z score for both groups. Patients who underwent HSCT<\/jats:styled-content> with Pesaro risk class II<\/jats:styled-content> or III<\/jats:styled-content> had higher risk for low BMD<\/jats:styled-content> compared to those risk class I patients (P<\/jats:italic>=.044). In conclusion, children with TM<\/jats:styled-content> who were >10\u00a0years at HSCT<\/jats:styled-content> are at risk for low BMD<\/jats:styled-content> and growth retardation. HSCT<\/jats:styled-content> had no effect on BMD<\/jats:styled-content> deficit in children with TM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12876","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T16:24:12Z","timestamp":1484238252000},"source":"Crossref","is-referenced-by-count":2,"title":["Effects of stem cell transplantation on bone mineral density and vitamin D status in children with thalassemia major"],"prefix":"10.1111","volume":"21","author":[{"given":"Dilek","family":"G\u00fcrlek G\u00f6k\u00e7ebay","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namik","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Children's Hematology and Oncology Hospital Ankara 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