{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:59:13Z","timestamp":1790258353729,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>3 is a hepatocyte canalicular membrane protein encoded by the <jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>4 gene located on chromosome 7. <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>3 mediates the translocation of phosphatidylcholine into bile. Severe <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content> 3 deficiency typically presents during early childhood with chronic cholestasis evolving to cirrhosis and portal hypertension, requiring liver transplantation. Herein, we report a case of severe <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>3 deficiency in a male child diagnosed with negative <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>3 immunostaining in hepatic canaliculi who underwent LDLT at our centre. We also describe single incidentally detected early well\u2010differentiated <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> in the explant liver. The patient is on regular follow\u2010up and is doing well. Our report shows that <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>3 deficiency may be a risk factor for the development of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12889","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T05:07:32Z","timestamp":1485493652000},"source":"Crossref","is-referenced-by-count":22,"title":["Hepatocarcinogenesis in multidrug\u2010resistant P\u2010glycoprotein 3 deficiency"],"prefix":"10.1111","volume":"21","author":[{"given":"Mukul","family":"Vij","sequence":"first","affiliation":[{"name":"Department of Pathology Global health city  Chennai Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh P.","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Institute of liver disease and transplantation Global health city  Chennai Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mettu Srinivas","family":"Reddy","sequence":"additional","affiliation":[{"name":"Institute of liver disease and transplantation Global health city  Chennai Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Govil","sequence":"additional","affiliation":[{"name":"Institute of liver disease and transplantation Global health city  Chennai Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Rela","sequence":"additional","affiliation":[{"name":"Institute of liver disease and transplantation Global health city  Chennai Tamilnadu India"},{"name":"National Foundation for Liver Research  Chennai Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.026187"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23539"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23984"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.1.282"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273427"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23947"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22485"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.044"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02148.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.01.025"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1202-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2015.06.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2010.08.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2014.03.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-19033"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90380-9"},{"key":"e_1_2_7_19_1","first-page":"1237","article-title":"Mice with homozygous disruption of the mdr2 P\u2010glycoprotein gene. 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