{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:39Z","timestamp":1753879179442,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pediatric <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> is a rare pediatric neoplasm and is distinctly different compared to adult <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>, often demonstrating translocation morphology evidenced by unique histopathological features and <jats:styled-content style=\"fixed-case\">TFE<\/jats:styled-content>3 or <jats:styled-content style=\"fixed-case\">TFEB<\/jats:styled-content> nuclear expression. We report three cases of pediatric <jats:styled-content style=\"fixed-case\">TFE<\/jats:styled-content>3 positive <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">TFE<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>) occurring in the setting of chronic kidney disease and long\u2010term pharmacological immunosuppression, including two cases that developed in the native kidney following kidney transplantation. Together, these cases suggest that the kidney microenvironment in combination with immune dysregulation is likely contributing factors in the pathogenesis of some pediatric <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>, warranting further study. Long\u2010term post\u2010transplant surveillance may warrant screening for <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12912","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T05:59:17Z","timestamp":1490162357000},"source":"Crossref","is-referenced-by-count":5,"title":["<scp>TFE<\/scp>3\u2010positive renal cell carcinoma occurring in three children with dysfunctional kidneys on immunosuppression"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-9666","authenticated-orcid":false,"given":"Beverly A.","family":"Schaefer","sequence":"first","affiliation":[{"name":"Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore S.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Medical College of Georgia Augusta University  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Hooper","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaimie D.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James I.","family":"Geller","sequence":"additional","affiliation":[{"name":"Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29368"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.4693"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23331"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20548"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1592"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e32834962bf"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12166"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00374.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-9106-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-1018-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-005-1471-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a238f6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09856.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12165"},{"issue":"4","key":"e_1_2_8_16_1","first-page":"34","article-title":"European best practice guidelines for renal transplantation. Section IV: long\u2010term management of the transplant recipient. IV.6.3. Cancer risk after renal transplantation. Solid organ cancers: prevention and treatment","volume":"17","author":"EBPG Expert Group on Renal Transplantation","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03630415"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11273.x"},{"issue":"3","key":"e_1_2_8_19_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the care of kidney transplant recipients","volume":"9","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group","year":"2009","journal-title":"Am J Transplant"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.08.082"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.28922"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:32:10Z","timestamp":1696149130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/petr.12912"],"URL":"https:\/\/doi.org\/10.1111\/petr.12912","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2017,3,21]]},"article-number":"e12912"}}