{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:37:39Z","timestamp":1787503059281,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>\n \n We aimed to determine whether malignancy after pediatric\n HT<\/jats:styled-content>\n x for\n ACM<\/jats:styled-content>\n affects overall post\u2010\n HT<\/jats:styled-content>\n x survival. Patients <18y listed for\n HT<\/jats:styled-content>\n x for\n ACM<\/jats:styled-content>\n in the\n PHTS<\/jats:styled-content>\n database between 1993 and 2014 were compared to those with\n DCM<\/jats:styled-content>\n . A 2:1 matched\n DCM<\/jats:styled-content>\n cohort was also compared. Wait\u2010list and post\u2010\n HT<\/jats:styled-content>\n x survival, along with freedom from common\n HT<\/jats:styled-content>\n x complications, were compared. Eighty subjects were listed due to\n ACM<\/jats:styled-content>\n , whereas 1985 were listed for\n DCM<\/jats:styled-content>\n . Although wait\u2010list survival was higher in the\n ACM<\/jats:styled-content>\n group, post\u2010\n HT<\/jats:styled-content>\n x survival was lower for the\n ACM<\/jats:styled-content>\n cohort. Neither difference persisted in the matched cohort analysis. Primary cause of death in the\n ACM<\/jats:styled-content>\n group was infection, which was higher than the\n DCM<\/jats:styled-content>\n group. Malignancy rates were not different. All\n ACM<\/jats:styled-content>\n malignancies were due to\n PTLD<\/jats:styled-content>\n without primary cancer recurrence or\n SMN<\/jats:styled-content>\n . Long\u2010term graft survival after pediatric\n HT<\/jats:styled-content>\n x for\n ACM<\/jats:styled-content>\n is no different than for matched\n DCM<\/jats:styled-content>\n peers, nor is there an increased risk of any malignancy. However, risk of infection and death from infection after\n HT<\/jats:styled-content>\n x are higher in the\n ACM<\/jats:styled-content>\n group. Further studies are needed to assess the effects of prior chemotherapy on susceptibility to infection in this group.\n <\/jats:p>","DOI":"10.1111\/petr.12923","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T13:47:15Z","timestamp":1491400035000},"source":"Crossref","is-referenced-by-count":29,"title":["Cancer recurrence and mortality after pediatric heart transplantation for anthracycline cardiomyopathy: A report from the Pediatric Heart Transplant Study (\n PHTS<\/scp>\n ) group"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1357-4698","authenticated-orcid":false,"given":"Matthew J.","family":"Bock","sequence":"first","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Pediatric Cardiology Loma Linda University Children's Hospital Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elfriede","family":"Pahl","sequence":"additional","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Cardiology Ann & Robert H. Lurie Children's Hospital of Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo G.","family":"Rusconi","sequence":"additional","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Pediatric Cardiology University of Miami Jackson Memorial Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Pediatric Cardiology Cleveland Clinic Foundation Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Parent","sequence":"additional","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Pediatric Cardiology Riley Hospital for Children Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare J.","family":"Twist","sequence":"additional","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Pediatric Hematology and Oncology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Kirklin","sequence":"additional","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Cardiovascular and Thoracic Surgery University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pruitt","sequence":"additional","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Cardiovascular and Thoracic Surgery University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Pediatric Heart Transplant Study (PHTS) Group Birmingham AL USA"},{"name":"Division of Pediatric Cardiology Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11407"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.4.1544"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182a88099"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa060185"},{"key":"e_1_2_9_6_1","unstructured":"RiesLA HarkinsD KrapchoM et\u00a0al.SEER Cancer Statistics Review 1975\u20102003. National Cancer Institute Bethesda MD 2006."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.08.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.08.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.01.910"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00453-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.10.048"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2002.02034.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(96)00310-7"},{"key":"e_1_2_9_14_1","unstructured":"PHTSManual of Operations: Forms Completion.http:\/\/www.uab.edu\/medicine\/phts\/images\/2010_Forms\/Revised_Manual_-_4.1.13.pdf. April 1 2013."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28763"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0107"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T18:56:47Z","timestamp":1696186607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/petr.12923"],"URL":"https:\/\/doi.org\/10.1111\/petr.12923","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]},"article-number":"e12923"}}