{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:32:53Z","timestamp":1753878773443,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fundac\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo","award":["2012\/12030-7"],"award-info":[{"award-number":["2012\/12030-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In pediatric liver transplantations with <jats:styled-content style=\"fixed-case\">LFS<\/jats:styled-content> grafts, higher incidences of graft dysfunction probably occur due to <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>. It was postulated that increasing the blood supply to the graft by means of a meso\u2010caval shunt could ameliorate the <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>. Eleven pigs underwent liver transplantation and were divided into two groups: <jats:styled-content style=\"fixed-case\">LFS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LFS<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">SHUNT<\/jats:styled-content> group. A series of flowmetric, metabolic, histologic, and molecular studies were performed. No significant metabolic differences were observed between the groups. One hour after reperfusion, portal flow was significantly lower in the recipients than in the donors, proving that the graft was maintained in low portal blood flow, although the shunt could promote a transient increase in the portal blood flow and a decrease in the arterial flow. Finally, it was verified that the shunt promoted a decrease in inflammation and steatosis scores and a decrease in the expression of the <jats:styled-content style=\"fixed-case\">eNOS<\/jats:styled-content> gene (responsible for the generation of nitric oxide in the vascular endothelium) and an increase in the expression of the proapoptotic gene <jats:italic><jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content><\/jats:italic>. The meso\u2010caval shunt was responsible for some positive effects, although other deleterious flowmetric and molecular alterations also occurred.<\/jats:p>","DOI":"10.1111\/petr.12928","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T08:25:05Z","timestamp":1493022305000},"source":"Crossref","is-referenced-by-count":2,"title":["Does a meso\u2010caval shunt have positive effects in a pig large\u2010for\u2010size liver transplantation model?"],"prefix":"10.1111","volume":"21","author":[{"given":"Ana Cristina Aoun","family":"Tannuri","sequence":"first","affiliation":[{"name":"Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30) Pediatric Surgery Division University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"de Albuquerque Rangel Moreira","sequence":"additional","affiliation":[{"name":"Pediatric Liver Transplantation Unit and 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