{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:13:40Z","timestamp":1784312020543,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,18]],"date-time":"2017-06-18T00:00:00Z","timestamp":1497744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the majority of long\u2010term survivors after <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>x, graft fibrosis has been identified. Recently, subtypes of graft fibrosis have been described based on their predominant acinar localization. We aimed to evaluate whether the development of portal, perisinusoidal, and centrilobular distribution of graft fibrosis is related to patient or transplantation\u2010related parameters. We reviewed the histological features in protocol liver biopsies taken at 1 and 5\u00a0years after <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>x of 47 children on a tacrolimus\u2010based immunosuppressive regimen. Fibrosis was assessed according to the <jats:styled-content style=\"fixed-case\">LAFS<\/jats:styled-content>c. The prevalence of portal fibrosis increased from 31% to 62%, sinusoidal from 68% to 79%, and centrilobular from 76% to 85%. The presence of portal fibrosis was associated with total bilirubin and \u03b3<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> levels (each <jats:italic>P<\/jats:italic>&lt;.02) and tended to be associated with biliary complications (<jats:italic>P<\/jats:italic>=.06). Sinusoidal fibrosis was associated with prior rejection episodes (<jats:italic>P<\/jats:italic>&lt;.02) and centrilobular fibrosis with the presence of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> mismatches (<jats:italic>P<\/jats:italic>=.02). In conclusion, using the <jats:styled-content style=\"fixed-case\">LAFS<\/jats:styled-content>c, we found a high incidence of progressive fibrosis in the 1\u2010year and 5\u2010year protocol biopsies after <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>x. Progression of fibrosis was observed in all acinar compartments, and each of the three locations is associated with different clinical conditions.<\/jats:p>","DOI":"10.1111\/petr.12988","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T04:06:53Z","timestamp":1497845213000},"source":"Crossref","is-referenced-by-count":10,"title":["Unique clinical conditions associated with different acinar regions of fibrosis in long\u2010term surviving pediatric liver grafts"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-2792","authenticated-orcid":false,"given":"Marjolein","family":"Baas","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Beatrix Children\u2019s Hospital University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette S. H.","family":"Gouw","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius C.","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouke G.","family":"Hepkema","sequence":"additional","affiliation":[{"name":"Laboratory of Transplant Immunology University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M. G. J.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Liver Transplantation University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HenkJan","family":"Verkade","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Beatrix Children\u2019s Hospital University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Scheenstra","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Beatrix Children\u2019s Hospital University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,18]]},"reference":[{"issue":"8","key":"e_1_2_9_2_1","first-page":"viii23","article-title":"Indications for pediatric liver transplantation. 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