{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:43Z","timestamp":1753879183451,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>De novo hepatocellular carcinoma (HCC<\/jats:styled-content>) post\u2010transplantation in patients without viral hepatitis is extremely rare, with only three reported adult cases in the English literature. Here, we present a case of de novo HCC<\/jats:styled-content> that developed in a 7\u2010year\u2010old female, who at 8 months of age received a liver, small bowel, spleen, and pancreas transplantation 6.5\u00a0years ago for gastroschisis and total parenteral nutrition (TPN<\/jats:styled-content>)\u2010related cirrhosis. The post\u2010transplant course was complicated by Epstein\u2010Barr virus (EBV<\/jats:styled-content>) infection, post\u2010transplant lymphoproliferative disease, and subsequent development of multifocal EBV<\/jats:styled-content>\u2010associated post\u2010transplant smooth muscle tumors (EBV<\/jats:styled-content>\u2010PTSMT<\/jats:styled-content>) in the small bowel 1 year and 10 months after transplantation, respectively. This was managed by reducing immunosuppression with rituximab and EBV<\/jats:styled-content>\u2010specific cytotoxic T\u2010cell therapy. She was noted to have a new lesion in her transplanted liver graft 6.5\u00a0years post\u2010transplantation that was diagnosed as HCC<\/jats:styled-content>. The HCC<\/jats:styled-content> was resected, and the patient remained clinically stable for 7\u00a0months. At that time, recurrence of the HCC<\/jats:styled-content> was discovered on MRI<\/jats:styled-content>. She passed away 6\u00a0months after. To the best of our knowledge, this is the first reported occurrence of de novo HCC<\/jats:styled-content> post\u2010transplantation in the pediatric population that is unrelated to viral hepatitis in either recipient or donor.<\/jats:p>","DOI":"10.1111\/petr.12991","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T10:22:46Z","timestamp":1501150966000},"source":"Crossref","is-referenced-by-count":5,"title":["De novo hepatocellular carcinoma post\u2010multivisceral transplantation in a child"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-7215","authenticated-orcid":false,"given":"P.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Pediatrics Keck School of Medicine Division of Gastroenterology Hepatology & Nutrition University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's Hospital of Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's Hospital of Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Finegold","sequence":"additional","affiliation":[{"name":"Department of Pathology Texas Children's Hospital Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mascarenas","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Children's Hospital of Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Alexopolous","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Keck School of Medicine Division of Gastroenterology Hepatology & Nutrition University of Southern California Los Angeles CA USA"},{"name":"Division of Abdominal Transplantation Department of Surgery Children's Hospital of Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Genyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Keck School of Medicine Division of Gastroenterology Hepatology & Nutrition University of Southern California Los Angeles CA USA"},{"name":"Division of Abdominal Transplantation Department of Surgery Children's Hospital of Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kerkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Keck School of Medicine Division of Gastroenterology Hepatology & Nutrition University of Southern California Los Angeles CA USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition Golisano Children's Hospital University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.11.032"},{"key":"e_1_2_4_3_1","first-page":"1021","article-title":"De novo hepatocellular carcinoma post liver transplantation: a case report and brief review of the literature","volume":"3","author":"Das R","year":"2015","journal-title":"J Liver Clin 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