{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:26:40Z","timestamp":1779236800197,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DIDS<\/jats:styled-content> is a unique form of combined immune deficiency characterized by an unusual susceptibility to cutaneous viral infections, severe allergies with eosinophilia and elevated immunoglobulin E titers, autoimmunity, and cancer. HSCT is considered the standard of care for this deadly disease. We have retrospectively analyzed the outcome of allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> from unrelated donors in patients with <jats:styled-content style=\"fixed-case\">DIDS<\/jats:styled-content>. Data from four patients, with five transplants, are presented. All patients received transplants from unrelated donors' BM, except for one patient who received a cord blood transplant. The conditioning regimens were based on myeloablative protocols for BM derived transplants; a NM regimen was pursued for the patient who received a cord blood transplant, which resulted in graft rejection. Although recurrent pneumonia and skin infections resolved immediately after transplantation, all patients subsequently developed human herpesvirus infection, including cutaneous herpetic lesions, cytomegalovirus reactivation, and zona zoster, which could be attributed to the use of ATG. Despite the presence of serious morbidities prior to transplantation, all patients recovered successfully. <jats:styled-content style=\"fixed-case\">DIDS<\/jats:styled-content> can be successfully treated with allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> from unrelated donors following a myeloablative conditioning regimen, with a reasonable safety profile.<\/jats:p>","DOI":"10.1111\/petr.13015","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T07:37:43Z","timestamp":1498808263000},"source":"Crossref","is-referenced-by-count":14,"title":["Hematopoietic stem cell transplantation from unrelated donors in children with <scp>DOCK<\/scp>8 deficiency"],"prefix":"10.1111","volume":"21","author":[{"given":"Dilara Fatma K.","family":"Uygun","sequence":"first","affiliation":[{"name":"Department of Pediatric Immunology Antalya Training and Research Hospital  Antalya 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