{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:14:16Z","timestamp":1782983656098,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The outcomes of pediatric ventricular assist device support in patients with diastolic heart failure have not been well described. This study reviews the North American experience with Berlin Heart <jats:styled-content style=\"fixed-case\">EXCOR<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> ventricular assist device implants in children with such physiology. The Berlin Heart clinical database was reviewed. Patients with primary diastolic dysfunction are included in this study. Twenty pediatric patients with restrictive cardiomyopathy (n\u00a0=\u00a013), hypertrophic cardiomyopathy (n\u00a0=\u00a03), or congenital heart disease with restrictive physiology (n\u00a0=\u00a04) who were supported with <jats:styled-content style=\"fixed-case\">EXCOR<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> were identified. Of these, nine (45%) were successfully bridged to transplant, one (5%) weaned from support, and 10 (50%) died after support was withdrawn. Of patients under age 3\u00a0years (n\u00a0=\u00a013), 38.5% survived, whereas those aged 3 or older (n\u00a0=\u00a07) had 71.4% survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.35). Biventricular assist device (BiVAD) patients experienced a 27.3% survival, vs 77.8% for patients with left ventricular assist device only (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.07). Primary causes of death included stroke, infection, acidosis, multisystem organ failure, and bleeding. Pediatric patients with diastolic heart failure comprise a high\u2010risk population for mechanical circulatory support. However, half of patients with this physiology have been successfully supported to explant with <jats:styled-content style=\"fixed-case\">EXCOR<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>. The trends toward higher mortality for younger patients and those receiving BiVAD support warrant consideration.<\/jats:p>","DOI":"10.1111\/petr.13048","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T08:43:18Z","timestamp":1505378598000},"source":"Crossref","is-referenced-by-count":34,"title":["Outcomes of Berlin Heart <scp>EXCOR<\/scp><sup>\u00ae<\/sup> pediatric ventricular assist device support in patients with restrictive and hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-0912","authenticated-orcid":false,"given":"Jennifer A.","family":"Su","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jondavid","family":"Menteer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.062"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)91136-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.104638"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.959288"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.02.083"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32835bfd85"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu233"},{"key":"e_1_2_9_9_1","first-page":"525","article-title":"Pediatric mechanical circulatory support in the United States: past, present, and future","volume":"52","author":"Duncan BW","year":"2006","journal-title":"ASAIO J"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2006.02.012"},{"key":"e_1_2_9_11_1","first-page":"S175","article-title":"Mechanical circulatory support and heart transplantation","volume":"11","author":"Hetzer R","year":"1992","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.978023"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014164"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000685"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12398"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.01.014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199507000-00064"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.08.085"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.08.031"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:28:55Z","timestamp":1695508135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,14]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/petr.13048"],"URL":"https:\/\/doi.org\/10.1111\/petr.13048","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,14]]},"article-number":"e13048"}}