{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:13:56Z","timestamp":1770488036519,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The impact of liver parenchymal abnormalities on survival post\u2010heart transplant remains unknown in pediatric Fontan patients. We assessed pediatric Fontan patients who underwent heart transplant and had documented pretransplant hepatic ultrasound (U\/S) studies. Liver U\/S findings were classified as normal (Group 1), mildly abnormal (Group 2, hepatomegaly\/vascular congestion), or severely abnormal (Group 3, heterogeneous echotexture\/nodularity). Among 30 study patients, 8 were classified as Group 1, 14 as Group 2, while 8 met Group 3 criteria. Pretransplant liver biochemistry and synthetic function were similar in all groups. Six Group 3 patients underwent liver biopsy; 4 demonstrated perisinusoidal or centrilobular fibrosis, and 2 had cirrhosis. Overall mortality was 30% (n\u00a0=\u00a09). Median follow\u2010up was 5\u00a0years (range, 0.25\u201013\u00a0years). One\u2010year survival was similar among all 3 groups (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.37), with a trend toward higher cumulative 5\u2010year survival in Group 1 (100%). The majority of pediatric Fontan patients who underwent heart transplant demonstrated abnormal preoperative liver ultrasound findings. Heterogeneous echotexture or nodularity detected on U\/S frequently indicates underlying liver parenchymal abnormalities. The presence of severe liver abnormalities was not associated with higher early mortality post\u2010heart transplant in pediatric Fontan patients; however, late outcomes must be further elucidated.<\/jats:p>","DOI":"10.1111\/petr.13061","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T04:02:45Z","timestamp":1509768165000},"source":"Crossref","is-referenced-by-count":9,"title":["Liver abnormalities and post\u2010transplant survival in pediatric Fontan patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8003-9746","authenticated-orcid":false,"given":"Sophie C.","family":"Hofferberth","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tajinder P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Bastardi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth D.","family":"Blume","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Fynn\u2010Thompson","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.26.3.240"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592378"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.052365"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.094516"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2011.00504.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.3.209"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.107177"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000243731.29657.87"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac60db"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.25879"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.03.077"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0022-5223(19)33989-3","article-title":"Specific sequelae after Fontan operation at mid\u2010 and long\u2010term follow\u2010up. 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